Evidence map›Paper›PMID 34180064›Full record

ArticleThe EMBO journal2021

LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy.

Paras Sehgal, Samatha Mathew, Ambily Sivadas, Arjun Ray, Jyoti Tanwar, Sushma Vishwakarma, Gyan Ranjan, K V Shamsudheen, Rahul C Bhoyar, Abhishek Pateria and 13 more

Open access · greenAbstract read
In one paragraph

Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 58 citations in OpenAlex.

  1. Trial
  2. Article
  3. Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell-Based Therapies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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  8. Bibliometric analysis of research hotspots and trends of lncRNA in angiogenesis-related diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
  9. Article
  10. Article
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  12. Genome-Wide Association Analysis Identifies LILRB2 Gene for Pathological Myopia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 3 institutions in 1 country.

Paras SehgalCSIR-Institute of Genomics and Integrative Biology, Delhi, India.ORCID 0000-0002-0593-8933
Samatha MathewCSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Ambily SivadasCSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Arjun RayCSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Jyoti TanwarCSIR-Institute of Genomics and Integrative Biology, Delhi, India.ORCID 0000-0001-9610-6405
Sushma VishwakarmaBrien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
Gyan RanjanCSIR-Institute of Genomics and Integrative Biology, Delhi, India.ORCID 0000-0003-3161-4796
K V ShamsudheenCSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Rahul C BhoyarCSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Abhishek PateriaCSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Elvin LeonardCSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Mukesh LalwaniCSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Archana VatsCSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Rajeev R PappuruKannuri Santhamma Centre for Retina and Vitreous, L V Prasad Eye Institute, Hyderabad, India.
Mudit TyagiKannuri Santhamma Centre for Retina and Vitreous, L V Prasad Eye Institute, Hyderabad, India.
Saumya JakatiBrien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
Shantanu SenguptaCSIR-Institute of Genomics and Integrative Biology, Delhi, India.
Binukumar B KCSIR-Institute of Genomics and Integrative Biology, Delhi, India.ORCID 0000-0003-0933-4691
Subhabrata ChakrabartiBrien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.ORCID 0000-0003-3717-4963
Inderjeet KaurBrien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
Rajender K MotianiLaboratory of Calciomics and Systemic Pathophysiology, Regional Center for Biotechnology, Faridabad, India.
Vinod ScariaCSIR-Institute of Genomics and Integrative Biology, Delhi, India.ORCID 0000-0001-7644-7181
Sridhar SivasubbuCSIR-Institute of Genomics and Integrative Biology, Delhi, India.ORCID 0000-0003-2411-4240
Institute of Genomics and Integrative Biology · INL V Prasad Eye Institute · INRegional Centre for Biotechnology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are emerging as key regulators of endothelial cell function. Here, we investigated the role of a novel vascular endothelial-associated lncRNA (VEAL2) in regulating endothelial permeability. Precise editing of veal2 loci in zebrafish (veal2

Indexed as

AgedAged, 80 and overAnimalsAnimals, Genetically ModifiedCase-Control StudiesDiabetic RetinopathyEmbryo, NonmammalianEndothelium, VascularGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsMiddle AgedPermeabilityProtein Kinase C betaRNA, Long NoncodingZebrafishPRKCB protein, humanProtein Kinase C betaRNA, Long NoncodingZebrafish Proteinsdiabetic retinopathydiacylglycerolendothelial permeabilitylong non-coding RNAprotein kinase C beta

Identifiers

PMID34180064
PMCPMC8327952
OpenAlexW3173828953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.