Trial reportEuropean heart journal2021
Eight-year outcomes for patients with aortic valve stenosis at low surgical risk randomized to transcatheter vs. surgical aortic valve replacement.
Trial report in European heart journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01057173 (Transcatheter Versus Surgical Aortic Valve Implantation in Patients With Severe Aortic Valve Stenosis), which is not on this map. Cited by 125 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcatheter Versus Surgical Aortic Valve Implantation in Patients With Severe Aortic Valve Stenosis
Who cites it
125 citing papers in PubMed, 7 syntheses or guidelines pooled it, 279 citations in OpenAlex.
- Comparison of short- and long-term outcomes between transcatheter and surgical aortic valve replacement for bicuspid aortic valve stenosis: a systematic review and meta-analysis.International journal of surgery (London, England) · 2026Pooled it
- Transcatheter or Surgical Treatment of Patients With Aortic Stenosis at Low to Intermediate Risk: An Individual Participant Data Meta-Analysis.JAMA cardiology · 2025Pooled it
- Current hotspot and study trend of transcatheter aortic valve replacement, a bibliometric analysis from 2009 to 2023.Frontiers in cardiovascular medicine · 2025Pooled it
- Harnessing the power of artificial intelligence in predicting all-cause mortality in transcatheter aortic valve replacement: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- Midterm Survival of Low-Risk Patients Treated With Transcatheter Versus Surgical Aortic Valve Replacement: Meta-Analysis of Reconstructed Time-to-Event Data.Journal of the American Heart Association · 2023Pooled it
- Transcatheter Aortic Valve Replacement vs. Surgical Aortic Valve Replacement for Long-Term Mortality Due to Stroke and Myocardial Infarction: A Meta-Analysis during the COVID-19 Pandemic.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Comparison of efficacy and safety between VKAs and DOACs in patients with atrial fibrillation after transcatheter aortic valve replacement: A systematic review and meta-analysis.Clinical cardiology · 2022Pooled it
- One-year outcomes of a novel balloon-expandable valve for severe aortic stenosis.BMC cardiovascular disorders · 2026Trial
- Blood flow dynamics in the ascending aorta of patients with bicuspid aortic valve before and after transcatheter aortic valve replacement: a computational fluid dynamics study.BMC cardiovascular disorders · 2024Trial
- Cost-effectiveness of transcatheter aortic valve implantation in patients at low surgical risk in France: a model-based analysis of the Evolut LR trial.The European journal of health economics : HEPAC : health economics in prevention and care · 2024Trial
- Transcatheter or surgical aortic valve implantation: 10-year outcomes of the NOTION trial.European heart journal · 2024Trial
- Lifetime management of patients with symptomatic severe aortic stenosis: a computed tomography simulation study.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2022Trial
- TAVR Explant in the Era of Lifetime Valve Management: Indications, Operative Challenges, and Contemporary Outcomes.Current cardiology reports · 2026Review
- Advances in Clinical Cardiology 2025: A Summary of Key Clinical Trials.Advances in therapy · 2026Review
- Time- and dose-dependent high-sensitivity cardiac troponin-T to improve outcome prediction after TAVI: a multicenter cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Nationwide trends and in-hospital outcomes of surgical versus transcatheter aortic valve replacement in Japan: a real-world analysis using administrative data.Heart and vessels · 2026Article
- Long-Term Outcomes of a Self-Expanding Transcatheter Heart Valve.Structural heart : the journal of the Heart Team · 2026Article
- The Legacy of the First Valve: Outcomes of Redo Surgical Aortic Valve Replacement After Prior Transcatheter Versus Prior Surgical Aortic Valve Replacement-A Narrative Review.Journal of clinical medicine · 2026Review
- Impact of early PR interval prolongation after transcatheter aortic valve Implantation (TAVI) on the onset of high-grade conduction disturbances.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Early Safety and Feasibility Study of a Novel Transcatheter Aortic Valve With Polymeric Leaflets.JACC. Asia · 2026Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
aimsThe aims of the study were to compare clinical outcomes and valve durability after 8 years of follow-up in patients with symptomatic severe aortic valve stenosis at low surgical risk treated with either transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR). METHODS AND
resultsIn the NOTION trial, patients with symptomatic severe aortic valve stenosis were randomized to TAVI or SAVR. Clinical status, echocardiography, structural valve deterioration, and failure were assessed using standardized definitions. In total, 280 patients were randomized to TAVI (n = 145) or SAVR (n = 135). Baseline characteristics were similar, including mean age of 79.1 ± 4.8 years and a mean STS score of 3.0 ± 1.7%. At 8-year follow-up, the estimated risk of the composite outcome of all-cause mortality, stroke, or myocardial infarction was 54.5% after TAVI and 54.8% after SAVR (P = 0.94). The estimated risks for all-cause mortality (51.8% vs. 52.6%; P = 0.90), stroke (8.3% vs. 9.1%; P = 0.90), or myocardial infarction (6.2% vs. 3.8%; P = 0.33) were similar after TAVI and SAVR. The risk of structural valve deterioration was lower after TAVI than after SAVR (13.9% vs. 28.3%; P = 0.0017), whereas the risk of bioprosthetic valve failure was similar (8.7% vs. 10.5%; P = 0.61).
conclusionsIn patients with severe aortic valve stenosis at low surgical risk randomized to TAVI or SAVR, there were no significant differences in the risk for all-cause mortality, stroke, or myocardial infarction, as well as the risk of bioprosthetic valve failure after 8 years of follow-up. CLINICAL
trial registrationURL: http://www.ClinicalTrials.gov. Unique identifier: NCT01057173.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.