Evidence map›Paper›PMID 34179955›Full record

ArticleBioinformatics (Oxford, England)2021

SysMod: the ISCB community for data-driven computational modelling and multi-scale analysis of biological systems.

Andreas Dräger, Tomáš Helikar, Matteo Barberis, Marc Birtwistle, Laurence Calzone, Claudine Chaouiya, Jan Hasenauer, Jonathan R Karr, Anna Niarakis, María Rodríguez Martínez and 2 more

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Boolean modelling as a logic-based dynamic approach in systems medicine.Computational and structural biotechnology journal · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andreas DrägerComputational Systems Biology of Infections and Antimicrobial-Resistant Pathogens, Institute for Bioinformatics and Medical Informatics (IBMI), University of Tübingen, 72076 Tübingen, Germany.
Tomáš HelikarDepartment of Biochemistry, University of Nebraska, Lincoln, NE 68588-0664, USA.
Matteo BarberisSystems Biology, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, Surrey, UK.
Marc BirtwistleDepartment of Chemical and Biomolecular Engineering, Clemson University, Clemson, SC 29634, USA.
Laurence CalzoneInstitut Curie, PSL Research University, Mines Paris Tech, Inserm, U900, F-75005 Paris, France.
Claudine ChaouiyaAix-Marseille Université, CNRS, Centrale Marseille, I2M, Marseille 2780-156, France.
Jan HasenauerInterdisicplinary Research Unit Mathematics and Life Sciences, University of Bonn, Bonn 53115, Germany.
Jonathan R KarrDepartment of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Anna NiarakisGenHotel, University of Evry, University of Paris-Saclay, Genopole, Évry 91025, France.
María Rodríguez MartínezIBM Research Europe, Zurich, CH-8803 Rüschlikon, Switzerland.
Julio Saez-RodriguezHeidelberg University, Faculty of Medicine and Heidelberg University Hospital, Institute of Computational Biomedicine, 69120 Heidelberg, Germany.
Juilee ThakarDepartment of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

Funding

TR&D3: Standards and Tools for Simulator Composition and Credibility portalP41EB023912 · NIBIB · UNIVERSITY OF WASHINGTON · PI HERBERT M. SAURO · 2018 to 2026
$11.4M
Software for collaborative construction, simulation, and analysis of mechanistic computational models of biological systemsR35GM119770 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Tomas Helikar · 2016 to 2026
$4.4M
Mechanistic Pharmacodynamic Modeling for Drug Combination ResponsesR35GM141891 · NIGMS · CLEMSON UNIVERSITY · PI BIRTWISTLE, MARC R. · 2021 to 2025
$2.1M
Toward whole-cell models for precision medicine and synthetic biologyR35GM119771 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KARR, JONATHAN ROSS · 2016 to 2020
$2.1M
NIBIB NIH HHS P41 EB023912NIGMS NIH HHS R35 GM119770NIGMS NIH HHS R35 GM119771NIGMS NIH HHS R35 GM141891
6 · The paper itself

Abstract

Computational models of biological systems can exploit a broad range of rapidly developing approaches, including novel experimental approaches, bioinformatics data analysis, emerging modelling paradigms, data standards and algorithms. A discussion about the most recent advances among experts from various domains is crucial to foster data-driven computational modelling and its growing use in assessing and predicting the behaviour of biological systems. Intending to encourage the development of tools, approaches and predictive models, and to deepen our understanding of biological systems, the Community of Special Interest (COSI) was launched in Computational Modelling of Biological Systems (SysMod) in 2016. SysMod's main activity is an annual meeting at the Intelligent Systems for Molecular Biology (ISMB) conference, which brings together computer scientists, biologists, mathematicians, engineers, computational and systems biologists. In the five years since its inception, SysMod has evolved into a dynamic and expanding community, as the increasing number of contributions and participants illustrate. SysMod maintains several online resources to facilitate interaction among the community members, including an online forum, a calendar of relevant meetings and a YouTube channel with talks and lectures of interest for the modelling community. For more than half a decade, the growing interest in computational systems modelling and multi-scale data integration has inspired and supported the SysMod community. Its members get progressively more involved and actively contribute to the annual COSI meeting and several related community workshops and meetings, focusing on specific topics, including particular techniques for computational modelling or standardisation efforts.

Indexed as

Computational BiologySystems BiologyAlgorithmsComputer SimulationData AnalysisHumans

Identifiers

PMID34179955
PMCPMC8570808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.