Evidence map›Paper›PMID 34179888›Full record

ReviewBiophysics reviews2021

Polyphasic linkage and the impact of ligand binding on the regulation of biomolecular condensates.

Kiersten M Ruff, Furqan Dar, Rohit V Pappu

Open access · hybridAbstract readReview
In one paragraph

Review in Biophysics reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. RNA G-Quadruplexes Function as a Tunable Switch of FUS Phase Separation.bioRxiv : the preprint server for biology · 2025
    Article
  9. A coarse-grained model for disordered proteins under crowded conditions.Protein science : a publication of the Protein Society · 2025
    Article
  10. Review
  11. Biomolecular condensates-Prerequisites for anhydrobiosis?Protein science : a publication of the Protein Society · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Dominance analysis to assess solute contributions to multicomponent phase equilibria.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Article
  19. Thermodynamic modulation of gephyrin condensation by inhibitory synapse components.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Phase separation of YAP-MAML2 differentially regulates the transcriptome.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kiersten M RuffDepartment of Biomedical Engineering and Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, Missouri 63130, USA.ORCID https://orcid.org/0000-0003-3240-1856
Furqan DarDepartment of Physics, Washington University in St. Louis, St. Louis, Missouri 63130, USA.ORCID https://orcid.org/0000-0002-3765-8506
Rohit V PappuDepartment of Biomedical Engineering and Center for Science and Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, Missouri 63130, USA.ORCID https://orcid.org/0000-0003-2568-1378
Washington University in St. Louis · US

Funding

ROLE OF CHAIN LENGTH AND SEQUENCE CONTEXTS ON POLYGLUTAMINE OLIGOMERIZATIONR01NS056114 · NINDS · WASHINGTON UNIVERSITY · PI PAPPU, ROHIT V · 2007 to 2020
$4.4M
Mechanism of modulation of huntingtin exon 1 aggregation by profilinR01NS089932 · NINDS · WASHINGTON UNIVERSITY · PI DIAMOND, MARC I, LANGEN, RALF · 2016 to 2020
$2.8M
NINDS NIH HHS R01 NS056114NINDS NIH HHS R01 NS089932
6 · The paper itself

Abstract

Cellular matter can be spatially and temporally organized into membraneless biomolecular condensates. The current thinking is that these condensates form and dissolve via phase transitions driven by one or more condensate-specific multivalent macromolecules known as scaffolds. Cells likely regulate condensate formation and dissolution by exerting control over the concentrations of regulatory molecules, which we refer to as ligands. Wyman and Gill introduced the framework of

Identifiers

PMID34179888
PMCPMC8211317
OpenAlexW3168173591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.