ArticleNature cancer2021
Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy.
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Article in Nature cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
110 citing papers in PubMed, 141 citations in OpenAlex.
- Toripalimab consolidation after chemoradiotherapy in limited-stage small cell lung cancer: a phase II, randomized controlled study (GASTO-1052A).Journal for immunotherapy of cancer · 2026Trial
- Adjuvant recombinant human endostatin combined with toripalimab (anti-PD-1) in locally advanced melanoma: an exploratory phase 2 clinical trial incorporating single-cell RNA/TCR/BCR sequencing.Molecular cancer · 2026Trial
- Adjuvant nivolumab, capecitabine or the combination in patients with residual triple-negative breast cancer: the OXEL randomized phase II study.Nature communications · 2024Trial
- Chronic interferon signaling at baseline is associated with acquired resistance to immunotherapy in metastatic melanoma.Cell reports. Medicine · 2026Article
- The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cells.Research square · 2026Article
- CD8MedComm · 2026Review
- Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis.Allergy · 2026Review
- Tumor-resident T cells and dendritic cells form an in situ archetype during immunotherapy response in melanoma.Nature communications · 2026Article
- Checkpoint inhibitors in microsatellite instability-high metastatic colorectal cancer: treatment strategies, specificities, and care management questions.ESMO gastrointestinal oncology · 2026Review
- Dual-Targeting Cuproptosis and Mitophagy via a Flavopiridol-Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reconsidering adjuvant and perioperative immune-checkpoint inhibition: de-escalation, expansion and personalization.Nature reviews. Clinical oncology · 2026Review
- The immunology of vitiligo.Nature reviews. Immunology · 2026Review
- Article
- Targeting PIM2 improves antitumor immunity through promoting effector function and persistence of CD8 T cells.The Journal of clinical investigation · 2026Article
- Dual regulation of CXCR6Journal for immunotherapy of cancer · 2026Article
- Early Mycophenolate Mofetil Combination Therapy as an Effective Approach for Immune-Related Hepatitis Induced by Immune Checkpoint Inhibitors in Patients With Solid Tumor.Cancer medicine · 2026Article
- Fgl2-knockout tumor cells serve as a vaccine inducing long-duration brain-resident memory T cells that reject subsequent intracranial tumor cell challenges.Cancer letters · 2026Article
- Tattoos and risk of cutaneous melanoma and nonmelanoma skin cancer in France.Journal of the National Cancer Institute · 2026Article
- Epigenetic regulation of T cell exhaustion in cancer.Nature reviews. Cancer · 2026Review
- Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Jichang HanDepartments of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.ORCID http://orcid.org/0000-0002-7964-8701
Yanding ZhaoDepartments of Molecular and Systems Biology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Keisuke ShiraiNorris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Aleksey MolodtsovDepartments of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Fred W KollingNorris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.ORCID http://orcid.org/0000-0002-6178-9901
Jan L FisherDepartments of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Peisheng ZhangNorris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Shaofeng YanDepartments of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.ORCID http://orcid.org/0000-0001-9654-2100
Tyler G SearlesNorris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Justin M BaderNorris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Jiang GuiNorris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Chao ChengBaylor School of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5002-3417
Marc S ErnstoffRoswell Park Cancer Institute, Buffalo, NY, USA.ORCID http://orcid.org/0000-0002-8132-7069
Mary Jo Turk *Departments of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. mary.jo.turk@dartmouth.edu.ORCID http://orcid.org/0000-0002-9612-8329
Christina V Angeles *Norris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. angelesc@med.umich.edu.ORCID http://orcid.org/0000-0002-6500-9589
Dartmouth College · USDartmouth–Hitchcock Medical Center · USBaylor School · USRoswell Park Comprehensive Cancer Center · US
Funding
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3MZhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI Jennifer Hong · 2019 to 2026
$27.2MTissue Resident memory T cell responses to cancerR01CA225028 · NCI · DARTMOUTH COLLEGE · PI Mary Jo Turk · 2018 to 2026
$4.9MSustaining Tissue Resident Memory T cellsR01CA254042 · NCI · DARTMOUTH COLLEGE · PI Yina Hsing Huang, Mary Jo Turk · 2022 to 2026
$2.6M10X Genomics Chromium Single-cell Sequencing to Expand Research At DartmouthS10OD025235 · OD · DARTMOUTH COLLEGE · PI TOMLINSON, CRAIG R · 2018 to 2018
$125kDefining a Transcriptional Signatures of Tissue-Resident T-cells in Melanoma through Single Cell RNA-seqF31CA232554 · NCI · DARTMOUTH COLLEGE · PI MOLODTSOV, ALEKSEY · 2018 to 2019
$90kNCI NIH HHS F31 CA232554NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA225028NCI NIH HHS R01 CA254042NIGMS NIH HHS P20 GM130454NIH HHS S10 OD025235
Abstract
While T-cell responses to cancer immunotherapy have been avidly studied, long-lived memory has been poorly characterized. In a cohort of metastatic melanoma survivors with exceptional responses to immunotherapy, we probed memory CD8
Indexed as
MelanomaMemory T CellsCD8-Positive T-LymphocytesHumansImmunologic FactorsImmunologic MemoryImmunotherapyImmunologic Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.