ArticleAnimal models and experimental medicine2021
Lipid bound extended release buprenorphine (high and low doses) and sustained release buprenorphine effectively attenuate post-operative hypersensitivity in an incisional pain model in mice (
Article in Animal models and experimental medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Analgesic drug efficacy in mouse postoperative pain: a systematic review and meta-analysis.Lab animal · 2026Pooled it
- Onset of Analgesia in Rats (Rattus norvegicus) for Three Buprenorphine Formulations.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Pharmacokinetics and Analgesic Efficacy of a Novel Extended-Release Buprenorphine Formulation in Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Efficacy and Pharmacokinetics of 3 Sustained-Release Buprenorphine Formulations in Cairo Spiny Mice (Acomys cahirinus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Buprenorphine extended-release (Ethiqa XR) impacts the immunological response in mice exposed to aerosolizedFrontiers in immunology · 2026Article
- The Analgesic Effect of Two Different Extended-Release Meloxicam Formulations for Attenuation of Hypersensitivity in Rats (Rattus norvegicus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Pharmacokinetic Analysis of Sustained-Release Buprenorphine Formulations in Owl Monkeys (Aotus spp.).Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Evaluation of Extended- and Immediate-Release Buprenorphine Formulations on Pharmacokinetics and Injection Site Lesions in Different Strains and Sex of Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Comparative Safety and Efficacy of Extended-Release Buprenorphine Formulations for Mouse Reproductive Surgeries under Tribromoethanol.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Pharmacokinetics of Extended-release Buprenorphine and Clinical Efficacy for Postoperative Pain Management in the Domestic Ferret (Journal of the American Association for Laboratory Animal Science : JAALAS · 2024Article
- Evaluation and comparison of pharmacokinetic profiles and safety of two extended-release buprenorphine formulations in common marmosets (Callithrix jacchus).Scientific reports · 2023Article
- Long-Acting Opioid Analgesics for Acute Pain: Pharmacokinetic Evidence Reviewed.Veterinary sciences · 2023Review
- Efficacy of Supplemental Diet Gels for Preventing Postoperative Weight Loss in Mice (Journal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- A Review of Long-acting Parenteral Analgesics for Mice and Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Review
- Post-Injury Buprenorphine Administration Is Associated with Long-Term Region-Specific Glial Alterations in Rats.Pharmaceutics · 2022Article
- Efficacy of 3 Buprenorphine Formulations for the Attenuation of Hypersensitivity after Plantar Incision in Immunodeficient NSG Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Pharmacokinetics of Sustained-release and Extended-release Buprenorphine in Mice after Surgical Catheterization.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Assessment of the Safety and Efficacy of Pre-emptive Use of Extended-release Buprenorphine for Mouse Laparotomy.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Effectiveness of two extended-release buprenorphine formulations during postoperative period in neonatal rats.PloS one · 2022Article
- Extended-release Buprenorphine, an FDAindexed Analgesic, Attenuates Mechanical Hypersensitivity in Rats (Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Extended-release buprenorphine (XR) is indicated for pain management in rodents, but little is known about its use in mice. This study aimed to investigate whether high dose XR effectively attenuates post-operative hypersensitivity better than low dose XR in a mouse model of incisional pain. Methods: Mice (n = 44) were randomly assigned to 1 of 4 treatment groups: (a) saline (1 ml/kg SC, once); (b) sustained release buprenorphine (Bup-SR, 1 mg/kg SC, once); (c) low dose extended-release buprenorphine (XR-lo, 3.25 mg/kg SC, once); (d) high dose extended-release buprenorphine (XR-hi, 6.5 mg/kg SC, once). On days -1, 0 (4 hours), 1, 2, and 3, mechanical and thermal hypersensitivities were evaluated, and plasma buprenorphine concentrations were measured. Results: Mechanical (days 0-2) and thermal (days 0-1) hypersensitivities were observed in the saline group. Bup-SR, XR-lo, and XR-hi attenuated mechanical hypersensitivity on days 0, 1, and 2. None of the treatment groups, except XR-Lo on day 0, attenuated thermal hypersensitivity on days 0 or 1. Plasma buprenorphine concentration peaked at 4 hours (day 0) in all treatment groups and remained greater than 1 ng/mL on days 0-2. No abnormal clinical observations or gross pathologic findings were seen in any groups. Conclusion: The results indicate XR-hi did not effectively attenuate post-operative hypersensitivity better than XR-lo. Thus both 3.25 and 6.5 mg/kg XR are recommended for attenuating post-operative hypersensitivity for at least up to 48 hours in mice.
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