Evidence map›Paper›PMID 34179708›Full record

ArticlePediatric investigation2021

A fatal case of liver abscess caused by hypervirulent

Yue Li, Zheng Li, Suyun Qian, Fang Dong, Qing Wang, Pengfei Zhang, Kaihu Yao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Biofilm-Mediated Antimicrobial Resistance in PediatricAntibiotics (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Article
  4. HypervirulentFrontiers in microbiology · 2024
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yue LiMOE Key Laboratory of Major Diseases in Children National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health China.
Zheng LiDepartment of Pediatric Intensive Care Unit Beijing Children's Hospital Capital Medical University National Center for Children's Health China.
Suyun QianDepartment of Pediatric Intensive Care Unit Beijing Children's Hospital Capital Medical University National Center for Children's Health China.
Fang DongDepartment of Clinical Microbiology Laboratory Beijing Children's Hospital Capital Medical University National Center for Children's Health China.
Qing WangMOE Key Laboratory of Major Diseases in Children National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health China.
Pengfei ZhangDepartment of Pediatric Intensive Care Unit Beijing Children's Hospital Capital Medical University National Center for Children's Health China.
Kaihu YaoMOE Key Laboratory of Major Diseases in Children National Key Discipline of Pediatrics (Capital Medical University) National Clinical Research Center for Respiratory Diseases Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health China.
Beijing Children’s Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceHypervirulent variants of

objectiveThis study aimed to report the clinical characteristics of hvKp that caused fatal PLA complicated by bacteremia in an adolescent and further identify the microbiological and genomic features of the causative strain.

methodsA 14-year-old boy with diabetes mellitus was admitted to our hospital with a diagnosis of PLA complicated by bacteremia. A hypermucoviscous hvKp strain, KPN_19-106, was isolated from the drainage fluid present within the liver abscess cavity and blood. The hypermucoviscosity phenotype of the causative strain was determined by string test. Its virulence was measured using serum resistance assay and

resultsKPN_19-106 belonged to sequence type 380 and serotype K2 and exhibited stronger serum resistance and higher

interpretationAntibiotic-susceptible hvKp can cause fatal PLA complicated by bacteremia in adolescents, with no improvement during antimicrobial therapy. The causative strain in this case had integrated multiple virulence genes and thus exhibited higher virulence both

Indexed as

Diabetes mellitusHypervirulentKlebsiella pneumoniaePediatric populationsPyogenic liver abscess

Identifiers

PMID34179708
PMCPMC8212719
OpenAlexW3122701046

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.