ArticlePediatric investigation2021
Plasma exchange therapy for acute necrotizing encephalopathy of childhood.
Article in Pediatric investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Clinical and genetic characteristics of RANBP2 mutations in children with acute necrotizing encephalopathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Defining the Clinicoradiologic Syndrome of SARS-CoV-2 Acute Necrotizing Encephalopathy: A Systematic Review and 3 New Pediatric CasesNeurology(R) neuroimmunology & neuroinflammation · 2024Pooled it
- Case report: Acute necrotizing encephalopathy: a report of a favorable outcome and systematic meta-analysis of outcomes with different immunosuppressive therapies.Frontiers in neurology · 2023Pooled it
- [Clinical features and prognosis of influenza-associated encephalopathy in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Decoding the lung-brain axis in influenza: from pulmonary infection to central nervous system injury.Journal of neuroinflammation · 2026Review
- High-dose methylprednisolone and tocilizumab improve survival of patients with high-risk pediatric acute necrotizing encephalopathy.Clinical and experimental pediatrics · 2026Article
- Bilateral Symmetrical Brain MRI Findings in Acute Necrotising Encephalopathy Type 1.Children (Basel, Switzerland) · 2025Article
- A rare case report: acute necrotizing encephalopathy and acute fulminant myocarditis.Frontiers in cardiovascular medicine · 2025Article
- Clinical characteristics and prognosis of paediatric respiratory syncytial virus-related encephalopathy.Italian journal of pediatrics · 2024Article
- Severe A(H1N1)pdm09 influenza acute encephalopathy outbreak in children in Tuscany, Italy, December 2023 to January 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Acute Necrotizing Encephalopathy in Adult Patients With COVID-19: A Systematic Review of Case Reports and Case Series.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Clinical characteristics and prognostic analysis of acute necrotizing encephalopathy of childhood: a retrospective study at a single center in China over 3 years.Frontiers in neurology · 2023Article
- Timing of therapeutic interventions against infection-triggered encephalopathy syndrome: a scoping review of the pediatric literature.Frontiers in neuroscience · 2023Article
- Article
- Plasma exchange therapy for acute necrotizing encephalopathy of childhood.Pediatric investigation · 2021Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
importanceAcute necrotizing encephalopathy (ANE) is a rare disease with high mortality. Plasma exchange (PLEX) has recently been reported to treat ANE of childhood (ANEC), but its efficacy is uncertain.
objectiveThis study aimed to investigate the effectiveness of PLEX on ANEC.
methodsA retrospective study was conducted in four pediatric intensive care units from December 2014 to December 2020. All patients who were diagnosed with ANEC were included; however, these patients were excluded if their length of stay was less than 24 h. Participants were classified into PLEX and non-PLEX groups.
resultsTwenty-nine patients with ANEC were identified, 10 in the PLEX group and 19 in the non-PLEX group. In the PLEX group, C-reactive protein, procalcitonin, alanine aminotransferase, and aspartate aminotransaminase levels were significantly lower after 3 days of treatment than before treatment (13.1
interpretationPLEX may reduce serum C-reactive protein and procalcitonin levels and improve liver function in the short term. PLEX may improve the prognosis of ANEC, and further studies are needed.
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