Evidence map›Paper›PMID 34179595›Full record

ArticleIEEE transactions on radiation and plasma medical sciences2021

Performance Characteristics of Long Axial Field-of-View PET Scanners with Axial Gaps.

Margaret E Daube-Witherspoon, Varsha Viswanath, Matthew E Werner, Joel S Karp

Abstract read
In one paragraph

Article in IEEE transactions on radiation and plasma medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Total-Body PET System Designs with Axial and Transverse Gaps: A Study of Lesion Quantification and Detectability.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  8. Total Body PET/CT: Future Aspects.Seminars in nuclear medicine · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Total-body PET: a new paradigm for molecular imaging.The British journal of radiology · 2022
    Review
  15. Total-Body PET: Will It Change Science and Practice?Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Margaret E Daube-WitherspoonDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104 USA.
Varsha ViswanathDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104 USA.
Matthew E WernerDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104 USA.
Joel S KarpDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104 USA.

Funding

EXPLORER: Changing the Molecular Imaging Paradigm with Total Body PETR01CA206187 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BADAWI, RAMSEY D., CHERRY, SIMON R · 2015 to 2019
$15.5M
Time-of-Flight PET for Improved Whole-Body ImagingR01CA113941 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JOEL S KARP, Suleman Surti · 2006 to 2026
$9.8M
Training Program in Biomedical Imaging and Information SciencesT32EB009384 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI GEE, JAMES C, IVES, ZACHARY · 2009 to 2023
$4.0M
PennPET Explorer Scanner With Scalable Axial Length for Total Body PET ImagingR01CA225874 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KARP, JOEL S · 2019 to 2023
$3.0M
NCI NIH HHS R01 CA113941NCI NIH HHS R01 CA206187NCI NIH HHS R01 CA225874NIBIB NIH HHS T32 EB009384
6 · The paper itself

Abstract

The introduction of long (>60 cm) axial field-of-view (LAFOV) PET systems has shown their potential for clinical and research applications. LAFOV scanners are expensive, so there is interest in designing systems with longer axial coverage while mitigating cost by introducing detector gaps. We used measurements on the PennPET Explorer (64-cm AFOV prototype) and simulations of scanners up to 143-cm long to assess scanner performance with axial gaps introduced by varying the number of detector rows in each ring. Removing detectors reduces the total sensitivity and results in a non-uniform axial noise profile. Axial resolution shows small (<0.5 mm) loss from the edge of the AFOV to the center, even for a 143-cm AFOV scanner with an unrestricted acceptance angle. The presence of large axial gaps increases the variability in axial resolution and contrast recovery across the AFOV compared to a system without gaps. More modest axial gaps show less variable behavior. The results suggest that designs where the gap is no larger than one-half of the width of a detector ring may be preferred, although the optimal choice of scanner design with the trade-offs of performance and AFOV will depend on its intended usage.

Indexed as

Long axial field of view PETPennPET ExplorerPET scanner design

Identifiers

PMID34179595
PMCPMC8224406

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.