ArticleAutism & developmental language impairments
The Social Responsiveness Scale (SRS-2) in school-age children with Down syndrome at low risk for autism spectrum disorder.
Article in Autism & developmental language impairments. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Efficacy and Safety of AltibrainCurrent pharmaceutical design · 2025Trial
- Effects of High-Phenolic Extra Virgin Olive Oil on Sensory Processing in Children With Autism Spectrum Disorder: A Pilot Study.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2026Article
- Regulation of Stress Physiology Across Social Contexts in Preterm-Born Preschoolers.Psychophysiology · 2026Article
- Caregiver-reported social foundations and cognitive regulation in toddlers with Down syndrome.Frontiers in psychiatry · 2026Article
- Short-term and Long-term Stability of the Autism Diagnostic Observation Schedule (ADOS-2) Calibrated Comparison Scores (CCS) and Classification Scores in Youth with Down Syndrome or Fragile X Syndrome with Intellectual Disability.Journal of autism and developmental disorders · 2026Article
- Characterizing Autism Traits in Toddlers with Down Syndrome: Preliminary Associations with Language, Executive Functioning, and Other Developmental Domains.Behavioral sciences (Basel, Switzerland) · 2025Article
- Contrasting Relationships Between Anxiety and Intolerance of Uncertainty in Cornelia de Lange and Fragile X Syndromes.Journal of intellectual disability research : JIDR · 2025Article
- Social and Quality-of-Life Impact of Refractive Surgery in Children With Developmental Disorders and Spectacle Nonadherence.American journal of ophthalmology · 2025Article
- Trisomy 21 and Congenital Heart Disease: Impact on Health and Functional Outcomes From Birth Through Adolescence: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2024Review
- Validation of factor structure of the neurodevelopmental parent report for outcome monitoring in down syndrome: confirmatory factor analysis.Frontiers in psychiatry · 2024Article
- Using the Social Skills Improvement System (SSiS) Rating Scales to assess social skills in youth with Down syndrome.Frontiers in psychology · 2023Article
- Associations among co-occurring medical conditions and cognition, language, and behavior in Down syndrome.Research in developmental disabilities · 2022Article
- Patterns and predictors of adaptive skills in 2- to 7-year-old children with Down syndrome.Journal of neurodevelopmental disorders · 2022Article
- Latent profiles of autism symptoms in children and adolescents with Down syndrome.Journal of intellectual disability research : JIDR · 2022Article
- Parenting Stress in Mothers of Children and Adolescents with Down Syndrome.Journal of clinical medicine · 2022Article
- Considerations for measuring individual outcomes across contexts in Down syndrome: Implications for research and clinical trials.International review of research in developmental disabilities · 2022Article
- Symptoms of Autism, Comorbid Mental Health Conditions and Challenging Behaviors among Toddlers with Down Syndrome at Low Risk for ASD-Characterization Using the BISCUIT-Parts 1-3.International journal of environmental research and public health · 2021Article
- Symptoms of Autism Spectrum Disorder in Individuals with Down Syndrome.Brain sciences · 2021Article
- Psychometric Evaluation of Social Cognition and Behavior Measures in Children and Adolescents with Down Syndrome.Brain sciences · 2021Article
- Humor Styles in Neurodevelopmental Conditions and Their Links to Social, Emotional, and Behavioral Strengths and Difficulties.Autism & developmental language impairmentsArticle
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
aimsLittle is known about how autism spectrum disorder (ASD) symptoms present in individuals with Down syndrome (DS). Some behaviors may be symptomatic of comorbid ASD or more broadly representative of the DS phenotype. A prior research study documented elevated ASD-like symptoms in adolescents and young adults with DS
methodsSRS-2 standard scores were analyzed in a sample of 40 children with DS, 6-11 years old, who were considered to be at low risk for ASD based on the Social Communication Questionnaire (SCQ) screener. Other developmental characteristics (i.e., age, nonverbal IQ, expressive language), social skills, and problem behaviors were also examined across the sample.
resultsSRS-2 scores were significantly elevated in this sample compared to the normative population sample. A pattern of ASD-like symptomatology was observed across SRS-2 subdomains. These findings were similar to the findings of the prior study. However, nuanced differences were observed across the two samples that may represent developmental differences across different ages in this population.
conclusionsReplicating and extending a prior study's findings, certain ASD-like behaviors may occur in individuals with DS who are at low risk for comorbid ASD. IMPLICATIONS: Understanding the pattern of ASD-like behaviors that occur in children with DS who are at low risk for comorbid ASD will help clinicians in screening and identification efforts. In particular, it will lead to better specification of the behaviors or symptoms that are not characteristic of the DS phenotype and thus are red flags for comorbid ASD in this population.
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