ArticleOpen medicine (Warsaw, Poland)2021
Mediastinal mixed germ cell tumor: A case report and literature review.
Article in Open medicine (Warsaw, Poland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Primary gastric mixed germ cell tumor in an infant: the pivotal role of dynamic alpha-fetoprotein surveillance in unmasking occult malignancy.BMC pediatrics · 2026Article
- Case Report: Extra skeletal Ewing's sarcoma of mediastinum: clinical experience and literature review.Frontiers in oncology · 2025Article
- A rare case of teratoma in the right atrium: A case report study.International journal of surgery case reports · 2024Article
- Article
- Metastatic right atrial mass in the presence of atrial septal defect: A rare clinical coincidence.Clinical case reports · 2024Article
- Spontaneous rupture‑induced life‑threatening mediastinal mixed germ cell tumor: A case report and therapeutic considerations.Oncology letters · 2024Article
- Primary mediastinal yolk sac tumor: A case report and literature review.Clinical case reports · 2023Article
- The Utility of Fine Needle Aspiration (FNA) Biopsy in the Diagnosis of Mediastinal Lesions.Diagnostics (Basel, Switzerland) · 2023Review
- A rare case of life-threatening mixed germ cell tumor infiltrating the heart: A case report.International journal of surgery case reports · 2023Article
- A rare case of brain metastatic of primary mediastinal yolk sac tumor.Radiology case reports · 2023Article
- [Mediastinal Teratoma: A Pictorial Essay].Taehan Yongsang Uihakhoe chi · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mixed germ cell tumor (MGCT) mainly occurs in young women's ovaries and men's testicles and rarely occurs outside the gonad. Fewer than 10 cases of mediastinal MGCT are available in PubMed, Embase, and other databases in English, while mediastinal MGCT with three pathological components, such as yolk sac tumor, immature teratoma, and embryonal carcinoma, has not been reported previously. A 12-year-old male sought medical attention for chest discomfort and underwent a computed tomography (CT) scan. A large soft tissue mass occupying most of the left thoracic cavity and mediastinum was detected. A CT-guided biopsy was performed, and an MGCT was diagnosed with pathological components, including yolk sac tumor, immature teratoma, and a small amount of embryonal carcinoma. Due to the large size of the tumor, the patient was treated with an EP regimen (etoposide + cisplatin) and paclitaxel + ifosfamide + cisplatin interstitial chemotherapy. The patient was followed up for 6 months and was alive with the disease. To the best of our knowledge, this is the 10th patient with MGCT in the mediastinum. The incidence of mediastinal MGCT is low, but it should still be considered one of the differential diagnoses of isolated pleural fibroma and neurogenic tumors.
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