Evidence map›Paper›PMID 34179348›Full record

ArticleAdvanced therapeutics2021

Superoxide Dismutase-Loaded Nanoparticles Attenuate Myocardial Ischemia-Reperfusion Injury and Protect Against Chronic Adverse Ventricular Remodeling.

Peter J Altshuler, Alexis R Schiazza, Lijun Luo, Mark R Helmers, Bonirath Chhay, Jason J Han, Robin Hu, D Alan Herbst, Andrew Tsourkas, Zhiliang Cheng and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

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  8. Synthetic Cells Revisited: Artificial Cells Construction Using Polymeric Building Blocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Peter J AltshulerDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Alexis R SchiazzaDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Lijun LuoDepartment of Bioengineering, University of Pennsylvania, 210 South 33 Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA.
Mark R HelmersDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Bonirath ChhayDepartment of Bioengineering, University of Pennsylvania, 210 South 33 Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA.
Jason J HanDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Robin HuDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
D Alan HerbstDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Andrew TsourkasDepartment of Bioengineering, University of Pennsylvania, 210 South 33 Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA.
Zhiliang ChengDepartment of Bioengineering, University of Pennsylvania, 210 South 33 Street, 240 Skirkanich Hall, Philadelphia, PA 19104, USA.
Pavan AtluriDivision of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
University of Pennsylvania · US

Funding

CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM008562 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WALTER K KRAFT, Scott A. Waldman · 1995 to 2026
$10.2M
Training Program in Biomedical Imaging and Information SciencesT32EB009384 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI GEE, JAMES C, IVES, ZACHARY · 2009 to 2023
$4.0M
A Novel Shear Thinning Hydrogel System for Advanced Cellular Therapy in Ischemic Heart DiseaseR01HL135090 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ATLURI, PAVAN · 2017 to 2021
$2.4M
Targeted treatment for radiculopathy via engineered PLA2-responsive multifunctional micellesR01NS100892 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI CHENG, ZHILIANG · 2017 to 2021
$1.7M
NHLBI NIH HHS R01 HL135090NIBIB NIH HHS T32 EB009384NIGMS NIH HHS T32 GM008562NINDS NIH HHS R01 NS100892
6 · The paper itself

Abstract

Early revascularization is critical to reduce morbidity after myocardial infarction, although reperfusion incites additional oxidative injury. Superoxide dismutase (SOD) is an antioxidant that scavenges reactive oxygen species (ROS) but has low endogenous expression and rapid myocardial washout when administered exogenously. This study utilizes a novel nanoparticle carrier to improve exogeneous SOD retention while preserving enzyme function. Its role is assessed in preserving cardiac function after myocardial ischemia-reperfusion (I/R) injury. Here, nanoparticle-encapsulated SOD (NP-SOD) exhibits similar enzyme activity as free SOD, measured by ferricytochrome-c assay. In an

Indexed as

ischemia-reperfusion injurynanoparticlereactive oxygen speciessemipermeablesuperoxide dismutase

Identifiers

PMID34179348
PMCPMC8225225
OpenAlexW3157370737

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.