Evidence map›Paper›PMID 34179344›Full record

ArticleAdvanced materials technologies2021

Conducting polymer-based granular hydrogels for injectable 3D cell scaffolds.

Vivian Rachel Feig, Sruthi Santhanam, Kelly Wu McConnell, Kathy Liu, Matine Azadian, Lucia Giulia Brunel, Zhuojun Huang, Helen Tran, Paul M George, Zhenan Bao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials technologies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  16. Smart bioelectronics and biomedical devices.Bio-design and manufacturing · 2022
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vivian Rachel Feig *Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.
Sruthi Santhanam *Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Kelly Wu McConnellDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Kathy LiuDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.
Matine AzadianDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Lucia Giulia BrunelDepartment of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA.
Zhuojun HuangDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.
Helen TranDepartment of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA.
Paul M GeorgeDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Zhenan BaoDepartment of Chemical Engineering, Stanford University, Stanford, CA, 94305, USA.

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
Optimizing Stem Cell-Enhanced Stroke Recovery through a Bioengineered Electrically Conductive Polymer ScaffoldK08NS089976 · NINDS · STANFORD UNIVERSITY · PI GEORGE, PAUL · 2015 to 2019
$940k
NIMH NIH HHS T32 MH020016NINDS NIH HHS K08 NS089976
6 · The paper itself

Abstract

Injectable 3D cell scaffolds possessing both electrical conductivity and native tissue-level softness would provide a platform to leverage electric fields to manipulate stem cell behavior. Granular hydrogels, which combine jamming-induced elasticity with repeatable injectability, are versatile materials to easily encapsulate cells to form injectable 3D niches. In this work, we demonstrate that electrically conductive granular hydrogels can be fabricated via a simple method involving fragmentation of a bulk hydrogel made from the conducting polymer PEDOT:PSS. These granular conductors exhibit excellent shear-thinning and self-healing behavior, as well as record-high electrical conductivity for an injectable 3D scaffold material (~10 S m

Indexed as

3D cell scaffoldsconductive hydrogelsinjectable hydrogels

Identifiers

PMID34179344
PMCPMC8225239

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.