ReviewOne health (Amsterdam, Netherlands)2021
Furin cleavage sites in the spike proteins of bat and rodent coronaviruses: Implications for virus evolution and zoonotic transfer from rodent species.
Review in One health (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- The Involvement of the Cryptococcal Yeast Kexin Protease in the Proteolytic Activation of the Uncleaved Influenza Virus Hemagglutinin Glycoprotein.MicrobiologyOpen · 2026Article
- From zoonotic spillover to endemicity: the broad determinants of human coronavirus tropism.mBio · 2025Review
- Coronaviruses in wild rodent and eulipotyphlan small mammals: a review of diversity, ecological implications and surveillance considerations.The Journal of general virology · 2025Review
- Recombination across distant coronavirid species and genera is a rare event with distinct genomic features.Journal of virology · 2024Article
- Assessment of genetic diversity, tissue tropism, and antigenic properties of Grimsö betacoronavirus in Swedish bank voles (One health (Amsterdam, Netherlands) · 2024Article
- Positive selection, genetic recombination, and intra-host evolution in novel equine coronavirus genomes and other members of theMicrobiology spectrum · 2024Article
- Structural basis for mouse receptor recognition by bat SARS2-like coronaviruses.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Identification and Characterization of an Alphacoronavirus inMicroorganisms · 2024Article
- Review
- Corona- and Paramyxoviruses in Bats from Brazil: A Matter of Concern?Animals : an open access journal from MDPI · 2023Review
- Detection and characterization of novel luchacoviruses, genusJournal of virology · 2023Article
- Challenges and Recent Advancements in COVID-19 Vaccines.Microorganisms · 2023Review
- Review
- Article
- The role of influenza-A virus and coronavirus viral glycoprotein cleavage in host adaptation.Current opinion in virology · 2023Review
- Natural selection differences detected in key protein domains between non-pathogenic and pathogenic Feline Coronavirus phenotypes.bioRxiv : the preprint server for biology · 2023Article
- Natural selection differences detected in key protein domains between non-pathogenic and pathogenic feline coronavirus phenotypes.Virus evolution · 2023Article
- Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Bats and rodents comprise two of the world's largest orders of mammals and the order Chiroptera (bats) has been implicated as a major reservoir of coronaviruses in nature and a source of zoonotic transfer to humans. However, the order Rodentia (rodents) also harbors coronaviruses, with two human coronaviruses (HCoV-OC43 and HCoV-HKU1) considered to have rodent origins. The coronavirus spike protein mediates viral entry and is a major determinant of viral tropism; importantly, the spike protein is activated by host cell proteases at two distinct sites, designated as S1/S2 and S2'. SARS-CoV-2, which is considered to be of bat origin, contains a cleavage site for the protease furin at S1/S2, absent from the rest of the currently known betacoronavirus lineage 2b coronaviruses (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.