ArticleIranian journal of biotechnology2021
Purification and Characterization of a Novel Fibrinolytic Enzyme from Cipangopaludina Cahayensis.
Article in Iranian journal of biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 4 citations in OpenAlex.
- Article
- Characterization of Gut Microbiome in the Mud SnailAnimals : an open access journal from MDPI · 2022Article
- Effects of cadmium exposure on intestinal microflora ofFrontiers in microbiology · 2022Article
- Thrombolytic Enzymes of Microbial Origin: A Review.International journal of molecular sciences · 2021Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCipangopaludina cahayensis contains active fibrinolytic proteins and has been considered a potential anti-cancer agent. However, its anti-cancer characteristics and functions have yet to be elucidated.
objectivesTo study the fibrinolytic activity and anticancer activity of crude protein extracts from Cipangopaludina cahayensis. MATERIALS AND
methodsCrude proteases were separated and extracted from the Cipangopaludina cahayensis through homogenization, desalting, ammonium sulfate fractionation, dialysis, and ion exchange chromatography. The fibrinolytic activity of extracted proteins was assessed using the fiber plate method. Total protein concentrations of the crude proteases were determined via BCA assay. Molecular weights (MWs) were determined through SDS-PAGE electrophoresis.
resultsThe crude extract had a MW of ~ 50 kDa, and the highest protein concentration was 3.026 mg.mL
conclusionsOur data showed that crude proteins purified from Cipangopaludina cahayensis are novel fibrinolytic proteases and have potential anti-cancer propertie.
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