Evidence map›Paper›PMID 34179097›Full record

ArticleFrontiers in molecular biosciences2021

Unexpected Gating Behaviour of an Engineered Potassium Channel Kir.

Charline Fagnen, Ludovic Bannwarth, Dania Zuniga, Iman Oubella, Rita De Zorzi, Eric Forest, Rosa Scala, Samuel Guilbault, Saïd Bendahhou, David Perahia and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Charline FagnenUMR 7590, CNRS, Muséum National d'Histoire Naturelle, Institut de Minéralogie, Physique des Matériaux et Cosmochimie, IMPMC, Sorbonne Université, Paris, France.
Ludovic BannwarthUMR 7590, CNRS, Muséum National d'Histoire Naturelle, Institut de Minéralogie, Physique des Matériaux et Cosmochimie, IMPMC, Sorbonne Université, Paris, France.
Dania ZunigaUMR 7590, CNRS, Muséum National d'Histoire Naturelle, Institut de Minéralogie, Physique des Matériaux et Cosmochimie, IMPMC, Sorbonne Université, Paris, France.
Iman OubellaUMR 7590, CNRS, Muséum National d'Histoire Naturelle, Institut de Minéralogie, Physique des Matériaux et Cosmochimie, IMPMC, Sorbonne Université, Paris, France.
Rita De ZorziDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy.
Eric ForestIBS University Grenoble Alpes, CNRS, CEA, Grenoble, France.
Rosa ScalaFaculté de Médecine, CNRS UMR7370, LP2M, Labex ICST, University Côte d'Azur, Nice, France.
Samuel GuilbaultFaculté de Médecine, CNRS UMR7370, LP2M, Labex ICST, University Côte d'Azur, Nice, France.
Saïd BendahhouFaculté de Médecine, CNRS UMR7370, LP2M, Labex ICST, University Côte d'Azur, Nice, France.
David PerahiaLaboratoire de Biologie et de Pharmacologie Appliquée, Ecole Normale Supérieure Paris-Saclay, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.
Catherine Vénien-BryanUMR 7590, CNRS, Muséum National d'Histoire Naturelle, Institut de Minéralogie, Physique des Matériaux et Cosmochimie, IMPMC, Sorbonne Université, Paris, France.
Institut de minéralogie, de physique des matériaux et de cosmochimie · FRLaboratoire de PhysioMédecine Moléculaire · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRÉcole Normale Supérieure Paris-Saclay · FRUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we investigated the dynamics and functional characteristics of the KirBac3.1 S129R, a mutated bacterial potassium channel for which the inner pore-lining helix (TM2) was engineered so that the bundle crossing is trapped in an open conformation. The structure of this channel has been previously determined at high atomic resolution. We explored the dynamical characteristics of this open state channel using an

Indexed as

HDX-mass spectrometrymolecular dynamics and normal modesmutation effectpotassium channel KirBac3.1single channel recording

Identifiers

PMID34179097
PMCPMC8222812
OpenAlexW3170579771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.