Evidence map›Paper›PMID 34179053›Full record

ReviewFrontiers in nutrition2021

Interplay Between Exercise and Gut Microbiome in the Context of Human Health and Performance.

Matthieu Clauss, Philippe Gérard, Alexis Mosca, Marion Leclerc

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 9 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 9 syntheses or guidelines pooled it, 255 citations in OpenAlex.

  1. Effects ofFrontiers in nutrition · 2026
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  9. Effects of Probiotics Supplementation on Risk and Severity of Infections in Athletes: A Systematic Review.International journal of environmental research and public health · 2022
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127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Matthieu ClaussUniversité Paris-Saclay, INRAE, AgroParisTech, MICALIS Institute, Jouy-en-Josas, France.
Philippe GérardUniversité Paris-Saclay, INRAE, AgroParisTech, MICALIS Institute, Jouy-en-Josas, France.
Alexis MoscaHôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Paris, France.
Marion LeclercUniversité Paris-Saclay, INRAE, AgroParisTech, MICALIS Institute, Jouy-en-Josas, France.
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FRMicrobiologie de l’alimentation au service de la santé · FRSorbonne Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota and exercise have recently been shown to be interconnected. Both moderate and intense exercise are typically part of the training regimen of endurance athletes, but they exert different effects on health. Moderate exercise has positive effects on the health of average athletes, such as a reduction in inflammation and intestinal permeability and an improvement in body composition. It also induces positive changes in the gut microbiota composition and in the microbial metabolites produced in the gastrointestinal tract. Conversely, intense exercise can increase gastrointestinal epithelial wall permeability and diminish gut mucus thickness, potentially enabling pathogens to enter the bloodstream. This, in turn, may contribute to the increase in inflammation levels. However, elite athletes seem to have a higher gut microbial diversity, shifted toward bacterial species involved in amino acid biosynthesis and carbohydrate/fiber metabolism, consequently producing key metabolites such as short-chain fatty acids. Moreover, rodent studies have highlighted a bidirectional relationship, with exercise impacting the gut microbiota composition while the microbiota may influence performance. The present review focuses on gut microbiota and endurance sports and how this interconnection depends upon exercise intensity and training. After pointing out the limits of the studies so far available, we suggest that taking into account the microbiota composition and its metabolic contribution to human host health could help in monitoring and modulating athletes' health and performance. Such an integrated approach should help in the design of microbiome-based solutions for health or performance.

Indexed as

gut microbial diversitygut microbial ecosysteminflammationprobioticssportomics

Identifiers

PMID34179053
PMCPMC8222532
OpenAlexW3171382660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.