Evidence map›Paper›PMID 34178987›Full record

ReviewFrontiers in cell and developmental biology2021

Spatiotemporal Insights Into RNA-Organelle Interactions in Neurons.

Shivani C Kharod, Dong-Woo Hwang, Sulagna Das, Young J Yoon

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shivani C KharodDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, United States.
Dong-Woo HwangDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, United States.
Sulagna DasDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, United States.
Young J YoonDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, United States.
Albert Einstein College of Medicine · US

Funding

Mechanism of MRNA Localization and Localized Translation in NeuronsR01NS083085 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Sulagna Das, Robert H Singer · 2013 to 2026
$9.0M
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Temporal dynamics of Arc (Arg3.1) transcriptional regulationR21MH122961 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DAS, SULAGNA · 2021 to 2022
$462k
NICHD NIH HHS P50 HD105352NIMH NIH HHS R21 MH122961NINDS NIH HHS R01 NS083085
6 · The paper itself

Abstract

Neurons exhibit spatial compartmentalization of gene expression where localization of messenger RNAs (mRNAs) to distal processes allows for site-specific distribution of proteins through local translation. Recently, there have been reports of coordination between mRNA transport with vesicular and organellar trafficking. In this review, we will highlight the latest literature on axonal and dendritic local protein synthesis with links to mRNA-organelle cotransport followed by emerging technologies necessary to study these phenomena. Recent high-resolution imaging studies have led to insights into the dynamics of RNA-organelle interactions, and we can now peer into these intricate interactions within subcellular compartments of neurons.

Indexed as

high-resolution imagingmRNA translationmRNA transportneuronsorganellar traffickingsingle molecule imagingvesicular trafficking

Identifiers

PMID34178987
PMCPMC8222803
OpenAlexW3168912160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.