ReviewJournal of diabetes and metabolic disorders2021
The rationale behind systematic reviews in clinical medicine: a conceptual framework.
Review in Journal of diabetes and metabolic disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Developing the Digital Health Communication Maturity Model: Systematic Review.Journal of medical Internet research · 2025Pooled it
- The medico-legal interpretation of diatom findings for the diagnosis of fatal drowning: a systematic review.International journal of legal medicine · 2025Pooled it
- Global trends and research gaps in deep brain stimulation for neurodevelopmental disorders: a scientometrics exploration of functional and behavioral outcomes.Frontiers in human neuroscience · 2025Pooled it
- Performance and Consistency of Large Language Models in Key Labor-Intensive Tasks of Systematic Reviews.Journal of evaluation in clinical practice · 2026Article
- From review to synthesis: A step-by-step methodological guide to systematic reviews and multilevel meta-analyses.Behavior research methods · 2026Article
- Two decades (2005 to 2025) of avian influenza research trends, knowledge gaps and distribution of emerging H5N1 2.3.4.4b clade in South Asia.One health outlook · 2026Article
- Article
- Development of a PRISMA extension for systematic reviews of health economic evaluations (PRISMA-EconEval): a project protocol.Systematic reviews · 2025Article
- An Autoethnographic Account of Familial Mediterranean Fever: A Turkish Patient's Discovery of Spiritual Meaning.Journal of religion and health · 2025Article
- Primary author contact for systematic reviews of randomized controlled trials: A systematic review.World journal of methodology · 2025Article
- Ages of sitting and walking milestone attainment in typically developing children worldwide: protocol for a scoping review.BMJ open · 2025Article
- Integrative technologies in nursing-led interventions for diabetes management: a systematic review of efficacy and outcomes.BMC nursing · 2025Article
- Large Language Model–Assisted Risk-of-Bias Assessment in Randomized Controlled Trials Using the Revised Risk-of-Bias Tool: Evaluation Study.Journal of medical Internet research · 2025Article
- Minority stress and stimulant use among US adult sexual minority men: A systematic review.Drug and alcohol dependence reports · 2025Review
- From Data to Recommendations: A Comprehensive Review of Ten Bibliometric Papers in Aesthetic Plastic Surgery.Aesthetic plastic surgery · 2025Review
- Evaluation of deep learning tools in medical diagnosis and treatment of cancer: research analysis of clinical and randomized clinical trials.Frontiers in network physiology · 2025Review
- Global Trends in Urological Evidence Synthesis: A Bibliometric Analysis of Systematic Reviews and Meta-analyses.Medical journal of the Islamic Republic of Iran · 2025Review
- A question-answering framework for automated abstract screening using large language models.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Machine Learning assisted systematic reviewing in orthopaedics.Journal of orthopaedics · 2024Article
- Methodological literature on the reporting of systematic reviews of health economic evaluations: a scoping review protocol.F1000Research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A systematic review (SR) is a type of review that uses a systematic method to provide a valid summary of existing literature addressing a clear and specific question. In clinical medicine (CM), the concept of SR is well recognized, especially after the introduction of evidence-based medicine; The SR of randomized clinical trials (RCTs) is considered the highest level of evidence on therapeutic effectiveness. Despite the popularity of the SRs and the increasing publication rate of SRs in CM and other healthcare literature, the concept has raised criticisms. Many of proper criticisms can be due to the deviation of some existing SRs from the original philosophy and well-established rationale behind the concept of SR. On the other hand, many criticisms are misconceptions about SRs which still exist even several decades after introducing the concept. This article presents a conceptual framework for clarifying the rationale behind SR in CM by providing the relevant concepts and their inter-relations, explaining how methodological standards of an SR and its rationale are connected, and discussing the rationale under the three-section: SR as a type of synthetic research, SR as a more informed and less biased review, and SR as an efficient scientific tool.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.