ArticleJournal of diabetes and metabolic disorders2021
Oxidative stress assessment and its relationship with the prevalence of atherogenic risk in patients with type 2 diabetes.
Article in Journal of diabetes and metabolic disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- The Role of the C-Reactive Protein-Triglyceride Glucose Index in Predicting New-Onset Chronic Diseases: Evidence From a Longitudinal Cohort Study.Brain and behavior · 2026Article
- Comparison of catalase, glutathione peroxidase and malondialdehyde levels in tears among diabetic patients with and without diabetic retinopathy.Journal of diabetes and metabolic disorders · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesDuring diabetes, prolonged hyperglycemia is characterized by the generation of free radicals via multiple mechanisms leading to various diabetic complications including cardiovascular diseases. This study aims to determine the relationship between a deregulation of the oxidative state in type 2 diabetes patients and the prevalence of atheroma plate formation.
methodsThis research was carried out at the Bouguerra Boulaares hospital and Alia Salah hospital in Tebessa, Algeria, on 560 patients with type 2 diabetes (300 women and 260 men), compared with 100 normal subjects (50 women and 50 men). For all subjects the following parameters were estimated: blood pressure, BMI (body mass index), glucose, glycated hemoglobin, total cholesterol, HDL Cholesterol, LDL Cholesterol, Triglycerides, Creatinine, serum redox status indicators (GSH, GPx, GSTs, and MDA) and a complete blood count was performed.
resultsThe findings of this study indicated a slight increase in arterial pressure in 336 diabetic patients (60%) with an HbA1c level between 7 and 9% (210 patients) and > 9% (126 patients); while the flow of the glomerular filtration remained within the norms for all the studied subjects. Patients showed an increase in blood glucose levels, disturbance of the lipid parameters with an increase in lipid peroxidation and a decrease in serum and erythrocyte antioxidant defense.
conclusionIt can be concluded that the formation of atheroma plate in diabetics is caused by the oxidation of circulating lipoproteins by free radicals generated following hyperglycemia, which can be avoided by supplementing antioxidant molecules such as antioxidant vitamins, trace elements.
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