ArticleJournal of diabetes and metabolic disorders2021
The investigation of the efficacy ratio of cress seeds supplementation to moderate hyperglycemia and hepatotoxicity in streptozotocin-induced diabetic rats.
Article in Journal of diabetes and metabolic disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 11 citations in OpenAlex.
- Effect ofCurrent drug metabolism · 2022Article
- Comparison of the Efficiency ofJournal of diabetes research · 2021Article
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4 authors at 1 institution in 1 country.
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Abstract
objectiveOxidative stress resulting from chronic hyperglycemia induced many complications in diabetes and led to disorders and dysfunctions in different organs. This study aimed to evaluate the hepatoprotective rate of cress seeds (CS) or
methodsDiabetes was induced by a single intraperitoneal injection of 60 mg/kg of streptozotocin (STZ). Forty-eight male rats were randomly divided into six groups : (D-0) and (ND-0) diabetic, and non-diabetic groups were fed with a normal diet, (ND-CS2) and (ND-CS5) non-diabetic groups were fed with diet containing 2 % and 5 % of cress seeds respectively, (D-CS2) and (D-CS5) diabetic groups were fed with diet containing 2 % and 5 % of cress seeds respectively. After 28 days of treatment, biochemical, histological, and oxidative parameters were determined. Hepatic and pancreatic histological sections were developed.
resultsSTZ-injection caused hyperglycemia accompanied by a disturbance in biochemical parameters and intensified oxidative stress status compared to the (ND-0) group. Hepatic and pancreatic histological sections of diabetic rats showed a disrupted architecture. However, the cress seeds-diet revealed a significant decrease of hyperglycemia and a reduction of the intensity of oxidative stress induced by diabetes compared to the (D-0) group, remarked by a decreased level of Malondialdehyde (MDA) and high levels of glutathione (GSH) and the antioxidant enzymes, led to the decrease of the majority of parameters principally hepatic and lipid profile with histological regeneration.
conclusionsCress seeds supplementation confirmed their potential anti-diabetic and antioxidant activities with higher efficacy of 5 % dose than the lower dose of 2 %. Therefore, 5 % of cress seeds administration seems to be the excellent rate recommended in controlling diabetes and its complications.
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