Evidence map›Paper›PMID 34178719›Full record

ArticleFrontiers in cellular and infection microbiology2021

Proteomic Analysis of Rhesus Macaque Brain Explants Treated With

Lianbao Li, Lisha Luo, Taigui Chen, Wenjing Cao, Xin Xu, Yu Zhang, Peng Yue, Yuxin Fan, Jingjing Chen, Meixiao Liu and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. A key protein fromIBRO neuroscience reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Lianbao LiDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Lisha LuoDepartment of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China.
Taigui ChenDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Wenjing CaoDepartment of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China.
Xin XuDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Yu ZhangDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Peng YueDepartment of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China.
Yuxin FanDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Jingjing ChenDepartment of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China.
Meixiao LiuDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Mingbiao MaDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Lvyan TaoDepartment of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China.
Yun PengDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Yan DongDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Bingxue LiDepartment of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China.
Suyi LuoDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Jing KongDepartment of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China.
Guozhong ZhouDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Shiyuan WenDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Aihua LiuDepartment of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China.
Fukai BaoDepartment of Microbiology and Immunology, Kunming Medical University, Kunming, China.
Kunming Medical University · CNKunming Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lyme neuroborreliosis (LNB) is one of the most dangerous manifestations of Lyme disease, but the pathogenesis and inflammatory mechanisms are not fully understood. Methods: Cultured explants from the frontal cortex of rhesus monkey brain (n=3) were treated with live Results: We identified 1237 differentially expressed proteins (DEPs; fold change ≥1.5 or ≤0.67, Conclusions: Elevated GAP-43 expression is a potential marker for LNB that may be useful for diagnosis or treatment.

Indexed as

Borrelia burgdorferiLyme NeuroborreliosisAnimalsBrainGAP-43 ProteinMacaca mulattaProteomicsGAP-43 ProteinBorrelia burgdorferiGAP-43HMC3lyme neuroborreliosisneuroinflammationproteomic analysis

Identifiers

PMID34178719
PMCPMC8224226
OpenAlexW3111565592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.