Evidence map›Paper›PMID 34178644›Full record

ReviewFrontiers in oncology2021

Regulation of Hippo, TGFβ/SMAD, Wnt/

Ammad Ahmad Farooqi, Sawera Nayyab, Chiara Martinelli, Rossana Berardi, Hector Katifelis, Maria Gazouli, William C Cho

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Ammad Ahmad FarooqiInstitute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.
Sawera NayyabDepartment of Biotechnology, Faculty of Science, University of Sialkot, Sialkot, Pakistan.
Chiara MartinelliIndependent researcher, Como, Italy.
Rossana BerardiUniversità Politecnica delle Marche-Ospedali Riuniti Ancona, Ancona, Italy.
Hector KatifelisLaboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Maria GazouliLaboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
William C ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China.
National and Kapodistrian University of Athens · GRInstitute of Biomedical and Genetic Engineering · PKMarche Polytechnic University · ITQueen Elizabeth Hospital · CNUniversity of Sialkot

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapidly evolving and ever-increasing knowledge of the molecular pathophysiology of pancreatic cancer has leveraged our understanding altogether to a next level. Compared to the exciting ground-breaking discoveries related to underlying mechanisms of pancreatic cancer onset and progression, however, there had been relatively few advances in the therapeutic options available for the treatment. Since the discovery of the DNA structure as a helix which replicates semi-conservatively to pass the genetic material to the progeny, there has been conceptual refinement and continuous addition of missing pieces to complete the landscape of central dogma. Starting from transcription to translation, modern era has witnessed non-coding RNA discovery and central role of these versatile regulators in onset and progression of pancreatic cancer. Long non-coding RNAs (lncRNAs) have been shown to act as competitive endogenous RNAs through sequestration and competitive binding to myriad of microRNAs in different cancers. In this article, we set spotlight on emerging evidence of regulation of different signaling pathways (Hippo, TGFβ/SMAD, Wnt/

Indexed as

apoptosislncRNAmicroRNApancreatic cancersignaling pathways

Identifiers

PMID34178644
PMCPMC8220219
OpenAlexW3171074411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.