Evidence map›Paper›PMID 34178577›Full record

ArticleAllergo journal international2021

Immunologically relevant aspects of the new COVID-19 vaccines-an ÖGAI (Austrian Society for Allergology and Immunology) and AeDA (German Society for Applied Allergology) position paper.

Eva Untersmayr, Elisabeth Förster-Waldl, Michael Bonelli, Kaan Boztug, Patrick M Brunner, Thomas Eiwegger, Kathrin Eller, Lisa Göschl, Katharina Grabmeier-Pfistershammer, Wolfram Hötzenecker and 20 more

Abstract read
In one paragraph

Article in Allergo journal international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Olfactory and gustatory disorders in COVID-19.Allergo journal international · 2022
    Review
  5. Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Eva UntersmayrInstitute of Pathophysiology and Allergy Research, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Elisabeth Förster-WaldlDepartment of Neonatology, Paediatric Intensive Care Medicine and Neuropaediatrics with Centre for Congenital Immunodeficiencies, University Clinics of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
Michael BonelliClinical Department of Rheumatology, University Clinics of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Kaan BoztugLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Patrick M BrunnerUniversity Clinics of Dermatology, Medical University of Vienna, Vienna, Austria.
Thomas EiweggerTranslational Medicine Program, Research Institute, Hospital for Sick Children, Toronto, Ontario Canada.
Kathrin EllerClinical Department of Nephrology, Internal Medicine, Medical University of Graz, Graz, Austria.
Lisa GöschlClinical Department of Rheumatology, University Clinics of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Katharina Grabmeier-PfistershammerInstitute of Immunology, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Wolfram HötzeneckerUniversity Clinics of Dermatology and Venereology, Kepler University Hospital, Comprehensive Allergy Centre, Linz, Austria.
Galateja JordakievaUniversity Clinics of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Vienna, Austria.
Alexander R MoschenUniversity Clinics of Internal Medicine, Department of Gastroenterology and Hepatology, Kepler University Hospital, Linz, Austria.
Birgit PfallerDepartment of Internal Medicine 1, Karl Landsteiner University of Health Sciences, University Hospital, St. Pölten, Austria.
Winfried PicklInstitute of Immunology, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Walter ReinischClinical Division of Gastroenterology and Hepatology, University Clinics of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Ursula WiedermannInstitute of Specific Prophylaxis and Tropical Medicine, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Ludger KlimekCentre for Rhinology and Allergology, Wiesbaden, Germany.
Karl-Christian BergmannDepartment of Dermatology, Venereology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Randolf BrehlerDepartment of Skin Diseases-General Dermatology and Venereology-Outpatient Clinic for Allergology, Occupational Dermatology and Environmental Medicine, University Hospital Münster, Münster, Germany.
Wolfgang PfütznerDepartment of Dermatology and Allergology, University Hospital Marburg (UKGM), Philipps University Marburg, Marburg, Germany.
Natalija NovakClinic and Polyclinic for Dermatology and Allergology, University Hospital Bonn, Bonn, Germany.
Hans MerkDepartment of Dermatology and Allergology, RWTH Aachen University, Aachen, Germany.
Uta RabeClinic for Allergology, Johanniter-Krankenhaus im Fläming Treuenbrietzen GmbH, Treuenbrietzen, Germany.
Wolfgang SchlenterAeDA-Ärzteverband Deutscher Allergologen, Langen-Dreieich, Germany.
Johannes RingSkin and Laser Centre at the Opera, Munich, Germany.
Wolfgang WehrmannDermatological Group Practice Wehrmann, Münster, Germany.
Norbert MülleneisenAsthma and Allergy Centre Leverkusen, Leverkusen, Germany.
Holger WredeNasal and Ear Specialist, Herford, Germany.
Thomas FuchsDepartment of Dermatology, Venereology and Allergology, University Medical Center Göttingen (UMG), Georg-August-University, Göttingen, Germany.
Erika Jensen-JarolimInstitute of Pathophysiology and Allergy Research, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe vaccines against the coronavirus disease 2019 (COVID-19) approved in the European Union represent a decisive step in the fight against the pandemic. The application of these available vaccines to patients with pre-existing immunological conditions leads to a multitude of questions regarding efficacy, side effects and the necessary patient information.

resultsThis review article provides insight into mechanisms of action of the currently available severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and summarises the current state of science as well as expert recommendations regarding tolerability of the vaccines. In addition, the potential to develop protective immune responses is determined. A special focus is given on patients under immunosuppression or in treatment with immunomodulatory drugs. Special groups of the population such as children, pregnant women and the elderly are also considered.

conclusionDespite the need for a patient-specific risk-benefit assessment, the consensus among experts is that patients with immunological diseases in particular benefit from the induced immune protection after COVID-19 vaccination and do not have an increased risk of side effects.

Indexed as

COVID-19 vaccinationImmune responseImmunomodulationImmunosuppressionVaccination effect

Identifiers

PMID34178577
PMCPMC8212077

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.