Evidence map›Paper›PMID 34178575›Full record

ArticleCurrent developmental disorders reports2021

Course of tic disorders over the lifespan.

Kevin J Black, Soyoung Kim, Nancy Y Yang, Deanna J Greene

Open access · greenAbstract read
In one paragraph

Article in Current developmental disorders reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Tourette syndrome.Nature reviews. Disease primers · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. The Prevalence of Tic Disorders in Poland: Regional and Sex Differences.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kevin J BlackDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, 63110.ORCID 0000-0002-6921-9567
Soyoung KimDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, 63110.ORCID 0000-0003-2983-604X
Nancy Y YangDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, 63110.ORCID 0000-0002-0786-0842
Deanna J GreeneDepartment of Cognitive Science, University of California, San Diego, La Jolla, California, 92093.ORCID 0000-0002-0739-7771
Washington University in St. Louis · USUniversity of California San Diego · US

Funding

The New Tics Study: A Novel Approach to Pathophysiology and Cause of Tic DisordersR01MH104030 · NIMH · WASHINGTON UNIVERSITY · PI BLACK, KEVIN J · 2017 to 2021
$3.3M
Longitudinal Study of Brain Imaging and Cognitive Markers of Tourette Syndrome in ChildrenR01MH118217 · NIMH · WASHINGTON UNIVERSITY · PI GREENE, DEANNA JACQUELYN · 2019 to 2025
$3.2M
NIMH NIH HHS R01 MH104030NIMH NIH HHS R01 MH118217
6 · The paper itself

Abstract

purpose of reviewTo summarize and update information on the course of tic disorders from childhood through later life. RECENT

findingsTics tend to improve substantially over the first year after they appear. However, contrary to widespread opinion, tics usually last longer than one year, though usually at minimal severity. Tics often wane to clinical insignificance over the teen years, possibly resurging occasionally over the lifespan. However, in an important minority of patients, tics remain clinically relevant throughout life. Tics rarely first come to clinical attention later in adulthood, but new reports describe additional such cases. SUMMARY: Recent publications have shown tics to persist past a few months more often than previously thought, though often at minimal severity, and recurrence after an asymptomatic period is common. The safety and efficacy of behavior therapy for tics, together with prospective indicators of early prognosis, make feasible the possibility of bettering the lifetime course of tic disorders with early intervention.

Indexed as

adultoutcomeprognosisProvisional Tic Disorderrecurrencespontaneous remissiontic disordersTourette syndrome

Identifiers

PMID34178575
PMCPMC8223879
OpenAlexW3155621177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.