Evidence map›Paper›PMID 34178358›Full record

ArticleAcute medicine & surgery

Japanese rapid/living recommendations on drug management for COVID-19.

Kazuma Yamakawa, Ryo Yamamoto, Go Ishimaru, Hideki Hashimoto, Takero Terayama, Yoshitaka Hara, Daisuke Hasegawa, Tadashi Ishihara, Haruki Imura, Hiromu Okano and 14 more

Open access · goldAbstract read
In one paragraph

Article in Acute medicine & surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Efficacy of favipiravir in adults with mild COVID-19: a randomized, double-blind, multicentre, placebo-controlled clinical trial.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Trial
  2. Article
  3. Article
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  6. Blood purification could tackle COVID-19?Journal of intensive care · 2021
    Article
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  11. PaOAcute medicine & surgery
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 19 institutions in 1 country.

Kazuma YamakawaDepartment of Emergency Medicine Osaka Medical and Pharmaceutical University Takatsuki Japan.
Ryo YamamotoDepartment of Emergency and Critical Care Medicine Keio University School of Medicine Tokyo Japan.
Go IshimaruDepartment of General Internal Medicine Soka Municipal Hospital Soka Japan.
Hideki HashimotoDepartment of Infectious Diseases The University of Tokyo Hospital Tokyo Japan.
Takero TerayamaDepartment of Psychiatry School of Medicine National Defense Medical College Tokorozawa Japan.
Yoshitaka HaraDepartment of Anesthesiology and Critical Care Medicine Fujita Health University School of Medicine Toyoake Japan.
Daisuke HasegawaDepartment of Anesthesiology and Critical Care Medicine Fujita Health University School of Medicine Toyoake Japan.
Tadashi IshiharaDepartment of Emergency and Critical Care Medicine Juntendo University Urayasu Hospital Urayasu Japan.
Haruki ImuraDepartment of Infectious Diseases Rakuwakai Otowa Hospital/Department of Health Informatics School of Public Health Kyoto University Kyoto Japan.
Hiromu OkanoDepartment of Critical Care and Emergency Medicine National Hospital Organization Yokohama Medical Center Kanagawa Japan.
Chihiro NaritaDepartment of Emergency Medicine and Intensive Care Medicine Shizuoka General Hospital Shizuoka Japan.
Takuya MayumiDepartment of Cardiovascular Medicine Graduate School of Medical Science Kanazawa University Kanazawa Japan.
Hideto YasudaDepartment of Emergency and Critical Care Medicine Jichi Medical University Saitama Medical Center Saitama Japan.
Kohei YamadaDepartment of Traumatology and Critical Care Medicine National Defense Medical College Tokorozawa Japan.
Hiroyuki YamadaDepartment of Primary Care and Emergency Medicine Kyoto University Hospital Kyoto Japan.
Tatsuya KawasakiDepartment of Pediatric Critical Care Shizuoka Children's Hospital Shizuoka Japan.
Nobuaki ShimeDepartment of Emergency and Critical Care Medicine Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan.
Kent DoiDepartment of Acute Medicine The University of Tokyo Tokyo Japan.
Moritoki EgiDivision of Anesthesiology Department of Surgery Related Kobe University Graduate School of Medicine Kobe Japan.
Hiroshi OguraDepartment of Traumatology and Acute Critical Medicine Osaka University Medical School Suita Japan.
Morio AiharaDepartment of Gastroenterology and Hematology Graduate School of Medicine of Hirosaki University Hirosaki Japan.
Hiroshi TanakaDepartment of Emergency and Critical Care Medicine Juntendo University Urayasu Hospital Urayasu Japan.
Osamu NishidaDepartment of Anesthesiology and Critical Care Medicine Fujita Health University School of Medicine Toyoake Japan.
Special Committee of the Japanese Clinical Practice Guidelines for the Management of Sepsis and Septic Shock 2020 (J‐SSCG 2020), the COVID‐19 Task Force
Fujita Health University · JPJuntendo University Urayasu Hospital · JPNational Defense Medical College · JPHirosaki University · JPHiroshima University · JPJichi Medical University Saitama Medical Center · JPKanazawa University · JPKeio University · JPKobe University · JPKyoto University · JPKyoto University Hospital · JPNational Hospital Organization · JPOsaka University · JPOsaka University of Pharmaceutical Sciences · JPShizuoka Children's Hospital · JPShizuoka General Hospital · JPSoka Municipal Hospital · JPThe University of Tokyo · JPUniversity of Tokyo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease (COVID-19) has spread worldwide since early 2020, and there are still no signs of resolution. The Japanese Clinical Practice Guidelines for the Management of Sepsis and Septic Shock (J-SSCG) 2020 Special Committee created the Japanese rapid/living recommendations on drug management for COVID-19 using the experience of creating the J-SSCGs. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) approach was used to determine the certainty of the evidence and strength of the recommendations. The first edition of this guideline was released on 9 September, 2020, and this document is the revised edition (version 3.1) (released 30 March, 2021). Clinical questions (CQs) were set for the following seven drugs: favipiravir (CQ1), remdesivir (CQ2), hydroxychloroquine (CQ3), corticosteroids (CQ4), tocilizumab (CQ5), ciclesonide (CQ6), and anticoagulants (CQ7). Favipiravir is recommended for patients with mild COVID-19 not requiring supplemental oxygen (GRADE 2C); remdesivir for moderate COVID-19 patients requiring supplemental oxygen/hospitalization (GRADE 2B). Hydroxychloroquine is not recommended for all COVID-19 patients (GRADE 1B). Corticosteroids are recommended for moderate COVID-19 patients requiring supplemental oxygen/hospitalization (GRADE 1B) and severe COVID-19 patients requiring ventilator management/intensive care (GRADE 1A); however, their use is not recommended for mild COVID-19 patients not requiring supplemental oxygen (GRADE 1B). Tocilizumab is recommended for moderate COVID-19 patients requiring supplemental oxygen/hospitalization (GRADE 2B). Anticoagulant therapy is recommended for moderate COVID-19 patients requiring supplemental oxygen/hospitalization and severe COVID-19 patients requiring ventilator management/intensive care (GRADE 2C). We hope that these clinical practice guidelines will aid medical professionals involved in the care of COVID-19 patients.

Indexed as

Coronavirusevidence‐based medicineGRADE approachpractice guidelineSIRS‐CoV‐2

Identifiers

PMID34178358
PMCPMC8209876
OpenAlexW3159501004

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.