ArticleTherapeutic advances in drug safety2021
Vaccine Safety Datalink infrastructure enhancements for evaluating the safety of maternal vaccination.
Article in Therapeutic advances in drug safety, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 44 citations in OpenAlex.
- Association Between COVID-19 Vaccination During Pregnancy and Safety Among Infants.Journal of the Pediatric Infectious Diseases Society · 2026Article
- Validation of pregnancy date estimation from outpatient electronic health record data.JAMIA open · 2026Article
- 2023-2024 COVID-19 vaccination coverage in pregnancy in ten healthcare delivery organizations in the United States.Vaccine · 2026Article
- Identifying pregnancies in routinely collected health data: a scoping review of methods.BMC medical informatics and decision making · 2026Article
- Ultrasound Procedure Codes Enable Timely Surveillance of Ongoing Pregnancies: A Nationwide Population-Based Register Study.Pharmacoepidemiology and drug safety · 2026Article
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- Strengths and limitations of non-survey-based data sources for assessing adult vaccination coverage in the United States.Expert review of vaccines · 2025Review
- Religious Service Attendance, COVID-19 Vaccine Attitudes, and COVID-19 Vaccination Status: A Vaccine Safety Datalink Member Survey, 2022-2023.AJPM focus · 2025Article
- Article
- Infant Respiratory Syncytial Virus Immunization Coverage in the Vaccine Safety Datalink: 2023-2024.Pediatrics · 2025Article
- Article
- Incidence and Risk Factors for Suicide Attempt During Pregnancy and the Postpartum Period.The Journal of clinical psychiatry · 2025Article
- Development of a Pregnancy Cohort in Commercial Insurance Claims Data: Evaluation of Deliveries Identified From Inpatient Versus Outpatient Claims.Pharmacoepidemiology and drug safety · 2025Article
- Trends in and characteristics of drug overdose morbidity among pregnant and postpartum individuals in California, 2010-2018.American journal of epidemiology · 2025Article
- Maternal Respiratory Syncytial Virus Vaccination and Receipt of Respiratory Syncytial Virus Antibody (Nirsevimab) by Infants Aged <8 Months - United States, April 2024.MMWR. Morbidity and mortality weekly report · 2024Article
- Characterisation and validation of lactation information from structured electronic health records for use in pharmacoepidemiological studies.Paediatric and perinatal epidemiology · 2024Article
- Attitudes Toward COVID-19 Vaccines Among Pregnant and Recently Pregnant Individuals.JAMA network open · 2024Article
- Racial and ethnic disparities in influenza vaccination coverage among pregnant women in the United States: The contribution of vaccine-related attitudes.Preventive medicine · 2023Article
- Who is pregnant? Defining real-world data-based pregnancy episodes in the National COVID Cohort Collaborative (N3C).JAMIA open · 2023Article
- The most common medications dispensed to lactating persons: An electronic health record-based approach.Pharmacoepidemiology and drug safety · 2023Article
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Authors and funding
19 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIdentifying pregnancy episodes and accurately estimating their beginning and end dates are imperative for observational maternal vaccine safety studies using electronic health record (EHR) data.
methodsWe modified the Vaccine Safety Datalink (VSD) Pregnancy Episode Algorithm (PEA) to include both the International Classification of Disease, ninth revision (ICD-9 system) and ICD-10 diagnosis codes, incorporated additional gestational age data, and validated this enhanced algorithm with manual medical record review. We also developed the new Dynamic Pregnancy Algorithm (DPA) to identify pregnancy episodes in real time.
resultsAround 75% of the pregnancy episodes identified by the enhanced VSD PEA were live births, 12% were spontaneous abortions (SABs), 10% were induced abortions (IABs), and 0.4% were stillbirths (SBs). Gestational age was identified for 99% of live births, 89% of SBs, 69% of SABs, and 42% of IABs. Agreement between the PEA-assigned and abstractor-identified pregnancy outcome and outcome date was 100% for live births, but was lower for pregnancy losses. When gestational age was available in the medical record, the agreement was higher for live births (97%), but lower for pregnancy losses (75%). The DPA demonstrated strong concordance with the PEA and identified pregnancy episodes ⩾6 months prior to the outcome date for 89% of live births.
conclusionThe enhanced VSD PEA is a useful tool for identifying pregnancy episodes in EHR databases. The DPA improves the timeliness of pregnancy identification and can be used for near real-time maternal vaccine safety studies. PLAIN LANGUAGE SUMMARY:
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