Evidence map›Paper›PMID 34178191›Full record

ArticleRadiology case reports2021

Sarcoidosis-lymphoma syndrome with portal hypertension: diagnostic clues and approach.

Fumio Chikamori, Kenji Yorita, Tadashi Yoshino, Satoshi Ito, Miki Mizobuchi, Koji Ueta, Kai Mizobuchi, Shigeto Shimizu, Kazumasa Nanjo, Sawaka Yukishige and 7 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Pathogenetic Mechanisms Linking Sarcoidosis to Lymphoma.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Fumio ChikamoriDepartment of Surgery, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Kenji YoritaDepartment of Diagnostic Pathology, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Tadashi YoshinoDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan.
Satoshi ItoDepartment of Radiology, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Miki MizobuchiDepartment of Internal Medicine, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Koji UetaDepartment of Surgery, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Kai MizobuchiDepartment of Surgery, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Shigeto ShimizuDepartment of Surgery, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Kazumasa NanjoDepartment of Surgery, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Sawaka YukishigeDepartment of Surgery, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Jun IwabuDepartment of Surgery, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Hisashi MatsuokaDepartment of Surgery, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Norihiro HokimotoDepartment of Surgery, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Hiromichi YamaiDepartment of Surgery, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Kazuhisa OnishiDepartment of Surgery, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Nobuyuki TanidaDepartment of Surgery, Japanese Red Cross Kochi Hospital, Kochi, Japan.
Niranjan SharmaDepartment of Surgery, Adv Train Gastroint & Organ Transp Surgery, Dunedin, New Zealand.
Japanese Red Cross Kochi Hospital · JPOkayama University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcoidosis-lymphoma syndrome associated with portal hypertension is very rare. A 68-year-old female presented with a 5 kg weight loss in 6 months. Soluble interleukin-2 receptor activity was increased and total platelet count was decreased. Contrast-enhanced computed tomography showed the presence of hepatosplenomegaly and a 3 cm-sized tumor in segment 3 of the liver. The hepatic venous catheterization showed mild portal hypertension. On fluorodeoxyglucose-positron emission tomography/computed tomography, progressive malignant lymphoma was suspected. However, bone marrow biopsy showed multiple noncaseating granulomas. A laparoscopic liver biopsy revealed that the liver tumor had features of Hodgkin lymphoma. There were multiple noncaseating epithelioid granulomas in the portal tracts of the liver. Splenectomy for splenomegaly and partial hepatectomy for the liver tumor were performed. Pathological examination of the resected specimens revealed multiple noncaseating epithelioid granulomas in the liver and spleen. Histopathology of the liver tumor confirmed classic Hodgkin lymphoma with mixed cellularity. We conclude that hepatic venous catheterization, positron emission tomography/computed tomography, and pathological examinations of bone marrow, liver, and spleen are crucial for the diagnosis of sarcoidosis-lymphoma syndrome associated with portal hypertension.

Indexed as

Hepatic sarcoidosisLaparoscopic liver biopsyPET/CTPortal hypertensionPrimary hepatic Hodgkin lymphomaSarcoidosis-lymphoma syndrome

Identifiers

PMID34178191
PMCPMC8213984
OpenAlexW3171069400

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.