ArticleTherapeutic advances in musculoskeletal disease2021
Intramuscular neridronate for the treatment of complex regional pain syndrome type 1: a randomized, double-blind, placebo-controlled study.
Article in Therapeutic advances in musculoskeletal disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews.The Cochrane database of systematic reviews · 2023Pooled it
- Evidence-Based Therapeutic Methods for Reflex Sympathetic Dystrophy: A Systematic Review.Cureus · 2026Review
- Intravenous Pamidronate in Persistent Complex Regional Pain Syndrome (CRPS): A Retrospective Observational Study on Effectiveness and Tolerability.Journal of pain research · 2026Article
- Tailoring Treatment in Complex Regional Pain Syndrome: A Comparative Study of Therapeutic Approaches in Complex Rehabilitation.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Evaluation of the efficacy and tolerance of pamidronate in complex regional pain syndrom type 1.Scientific reports · 2025Observational
- Isolated Navicular Algodystrophy and Abnormal Capillaroscopic Pattern in a 50-year-old Smoker: A Possible Microvascular Connection.Mediterranean journal of rheumatology · 2025Article
- Transient osteoporosis of the hip and fatty liver disease: Case report and pathogenic hypothesis.The Journal of international medical research · 2025Article
- The Effect of Fremanezumab on Pain in Patients with Complex Regional Pain Syndrome: Study Protocol of a Randomized, Double-Blind, Proof-of-Concept, Placebo-Controlled Trial.Brain sciences · 2025Article
- Conservative treatments of bone marrow lesions.Journal of experimental orthopaedics · 2025Article
- 10. Complex regional pain syndrome.Pain practice : the official journal of World Institute of Pain · 2025Review
- Retrospective Analysis of 28 Cases of Complex Regional Pain Syndrome.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2025Article
- Review
- Benign Evolution of Complex Regional Pain Syndrome (CRPS) Type 1 in Patients Treated with Intravenous Neridronate: A Single-Center Real-Life Experience.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Bone Turnover Markers and Wnt Signaling Modulators in Early Complex Regional Pain Syndrome. A Pre-specified Observational Study.Calcified tissue international · 2024Observational
- No Significant Differences between Bisphosphonates and Placebo for the Treatment of Bone Marrow Lesions of the Knee: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2024Review
- Efficacy and Safety of Pharmacological Treatment in Patients with Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Is CRPS-1 a Chronic Disabling Disease? A Long-term, Real-Life Study on Patients Treated With Neridronate.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2024Article
- The challenge of pharmacotherapy for musculoskeletal pain: an overview of unmet needs.Therapeutic advances in musculoskeletal disease · 2024Review
- Modern Principles of Diagnosis and Treatment in Complex Regional Pain Syndrome.Deutsches Arzteblatt international · 2022Article
- How to Treat Algodystrophy and Rheumatic Comorbidity in Myelofibrosis: Three Case Reports.Cureus · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComplex regional pain syndrome type-1 (CRPS-1) is a severely disabling painful disease challenging to treat. This multicenter, randomized, double-blind placebo-controlled trial examined the efficacy of intramuscular (i.m.) neridronate in CRPS-1 patients.
methodsA total of 78 patients diagnosed with CRPS-1 (aged 59.5 ± 10.3, 66.7% female) were randomly assigned to 25 mg (i.m.) neridronate (
resultsAfter 30 days, VAS score decreased significantly to a greater extent in neridronate-treated patients
conclusionIn patients with acute CRPS-1, i.m. injections of 25 mg neridronate were associated with clinically relevant benefit compared with placebo controls.
trial registrationEU Clinical Trials Register: https://www.clinicaltrialsregister.eu/ctr-search/search?query=2014-001156-28.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.