Evidence map›Paper›PMID 34178012›Full record

ArticleDementia and geriatric cognitive disorders extra

Characteristics of Regional Cerebral Blood Flow in Alzheimer Disease and Amnestic Mild Cognitive Impairment by Single-Photon Emission Computerized Tomography: A Cross-Sectional Study.

Yota Kunieda, Chiaki Arakawa, Takumi Yamada, Mizue Suzuki, Shingo Koyama, Yosuke Kimura, Takeo Ichikawa, Shuhei Shino, Minoru Yamada, Ryuto Hirokawa and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Yota KuniedaDepartment of Rehabilitation, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
Chiaki ArakawaDepartment of Internal Medicine, Musubiha Clinic Shibuya, Tokyo, Japan.
Takumi YamadaGraduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Mizue SuzukiDepartment of Rehabilitation, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
Shingo KoyamaDepartment of Rehabilitation, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
Yosuke KimuraGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan.
Takeo IchikawaGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan.
Shuhei ShinoGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan.
Minoru YamadaGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan.
Ryuto HirokawaDepartment of Radiology and Nuclear Medicine, Akita Cerebrospinal and Cardiovascular Center, Akita, Japan.
Tadamitsu MatsudaDepartment of Physical Therapy, Faculty of Health Sciences, Juntendo University, Tokyo, Japan.
Tomokazu TakakuraDepartment of Rehabilitation, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
Tomohide AdachiDementia-Related Disease Medical Center, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Haruhiko HoshinoDementia-Related Disease Medical Center, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
University of Tsukuba · JPSaiseikai Central Hospital · JPTokyo Metropolitan Geriatric Hospital · JPJuntendo University · JPShibuya (Japan) · JPTokyo Metropolitan University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe regional cerebral blood flow (rCBF) distribution can affect brain functioning, leading to amnestic mild cognitive impairment (aMCI) and mild Alzheimer disease (AD). This study aimed to clarify the detailed characteristics of rCBF distribution in patients with mild AD and aMCI.

methodsThis cross-sectional study from April 2015 to March 2018 included 103 older adults (mean age 78.9 years; 60% females), out of a total of 302 adults, and categorized them into 3 groups according to cognitive symptoms. The normal control (NC), aMCI, and mild AD groups included 20, 50, and 33 participants, respectively. The primary outcome was rCBF, which was compared among the 3 groups using a 2-sample

resultsIn the aMCI group, the rCBF decreased in the bilateral parietal and left frontal association cortex and the bilateral premotor cortex (

conclusionBased on the analysis of the values obtained, it was inferred that the rCBF undergoes reduction and elevation in aMCI and AD patients.

Indexed as

Alzheimer dementiaCross-sectional studyMild cognitive impairmentRegional cerebral blood flowSingle-photon emission computerized tomography

Identifiers

PMID34178012
PMCPMC8215965
OpenAlexW3159680733

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.