Evidence map›Paper›PMID 34177968›Full record

ReviewFrontiers in immunology2021

Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment.

Ellen N Scott, Angela M Gocher, Creg J Workman, Dario A A Vignali

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 174 citations in OpenAlex.

  1. Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Trial
  2. Review
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  10. Overcoming tumour resistance in cancer immunotherapy through predictive and pharmacodynamic biomarkers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  11. GlycoChat Uncovers Glycan-Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. GPCR Biased Signaling in Cancer.Handbook of experimental pharmacology · 2026
    Review
  17. Review
  18. LGMNFrontiers in immunology · 2026
    Article
  19. Article
  20. Article

77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Ellen N ScottDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Angela M GocherDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Creg J WorkmanDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Dario A A VignaliDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
University of Pittsburgh · USUniversity of Pittsburgh Medical Center · USUPMC Hillman Cancer Center · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Synergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Dario AA Vignali · 2015 to 2026
$30.8M
Training in Cellular & Molecular Mechanisms of Tumor RejectionT32CA082084 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert J Binder, Dario AA Vignali · 1999 to 2026
$9.2M
Interleukin-35 and the tumor microenvironmentR01CA203689 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VIGNALI, DARIO AA · 2016 to 2020
$1.9M
Production of Interferon Gamma by Regulatory T Cells Mediates Response to ImmunotherapyF32CA247004 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOCHER-DEMSKE, ANGELA MARIE · 2020 to 2022
$206k
NCI NIH HHS F32 CA247004NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA203689NIAID NIH HHS P01 AI108545
6 · The paper itself

Abstract

Regulatory T cells (T

Indexed as

AnimalsHumansT-Lymphocytes, RegulatoryTumor EscapeTumor Microenvironmentcancerimmune infiltrationregulatory T cells (Treg)stromatumor microenvironmentvasculature

Identifiers

PMID34177968
PMCPMC8222776
OpenAlexW3168968023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.