Evidence map›Paper›PMID 34177931›Full record

ArticleFrontiers in immunology2021

Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis.

Richard Ahn, Damjan Vukcevic, Allan Motyer, Joanne Nititham, David McG Squire, Jill A Hollenbach, Paul J Norman, Eva Ellinghaus, Rajan P Nair, Lam C Tsoi and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Psoriasis Area and Severity Index (PASI) Objectivisation by Flow Cytometry Analysis of Major Lymphocytes Subsets.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2023
    Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 4 countries.

Richard AhnDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States.
Damjan VukcevicMelbourne Integrative Genomics, The University of Melbourne, Parkville, VIC, Australia.
Allan MotyerMelbourne Integrative Genomics, The University of Melbourne, Parkville, VIC, Australia.
Joanne NitithamDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, United States.
David McG SquireMelbourne Integrative Genomics, The University of Melbourne, Parkville, VIC, Australia.
Jill A HollenbachDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
Paul J NormanDivision of Personalized Medicine, Department of Immunology and Microbiology, University of Colorado, San Francisco, CA, United States.
Eva EllinghausInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Rajan P NairDepartment of Dermatology, University of Michigan, Ann Arbor, MI, United States.
Lam C TsoiDepartment of Dermatology, University of Michigan, Ann Arbor, MI, United States.
Jorge OksenbergDepartment of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States.
John FoersterCollege of Medicine, Dentistry, and Nursing, University of Dundee, Dundee, United Kingdom.
Wolfgang LiebInstitute of Epidemiology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Stephan WeidingerDepartment of Dermatology, University Hospital Schleswig Holstein, Kiel, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
James T ElderDepartment of Dermatology, University of Michigan, Ann Arbor, MI, United States.
Eric JorgensonDivision of Research, Kaiser Permanente, Oakland, CA, United States.
Stephen LeslieMelbourne Integrative Genomics, The University of Melbourne, Parkville, VIC, Australia.
Wilson LiaoDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, United States.
University of California, San Francisco · USChristian-Albrechts-Universität zu Kiel · DEUniversity of Michigan · USMelbourne Genomics Health Alliance · AUThe University of Melbourne · AUKaiser Permanente · USQB3 · USUniversity Hospital Schleswig-Holstein · DEUniversity of Dundee · GB

Funding

ZINC GLUCONATE GLYCINE LOZENGES &VITAMIN C EFFECTS ON COMMON COLDM01RR000042 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELSTROM, REBECCA L · 1985 to 2007
$40.8M
Insights Into Immune-Related Diseases Born from Population GenomicsU01AI090905 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Paul John Norman · 2010 to 2026
$10.9M
Linkage analysis of familial psoriasis(Supplement)R01AR042742 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 1994 to 2021
$10.1M
Genetic and Genomic Dissection of Psoriatic ArthritisR01AR063611 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD, GLADMAN, DAFNA D · 2012 to 2023
$6.2M
UCSF Dermatology Training GrantT32AR007175 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wilson Liao, Michael David Rosenblum · 1986 to 2026
$6.1M
Identification of Psoriatic Arthritis Genes in the MHCR01AR050511 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2004 to 2013
$4.2M
MHC and KIR Region Genomics in PsoriasisU01AI119125 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIAO, WILSON · 2015 to 2019
$3.5M
Functional Genomics of PsoriasisR01AR065183 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2013 to 2016
$1.7M
Genotyping the NPF Biobank for Psoriasis Susceptibility GenesRC1AR058315 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2009 to 2010
$993k
Design Approaches for Sequencing Disease-Associated Regions in PsoriasisU01HG005924 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELDER, JAMES TILFORD · 2010 to 2010
$221k
NCRR NIH HHS M01 RR000042NHGRI NIH HHS U01 HG005924NIAID NIH HHS U01 AI090905NIAID NIH HHS U01 AI119125NIAMS NIH HHS R01 AR042742NIAMS NIH HHS R01 AR050511NIAMS NIH HHS R01 AR063611NIAMS NIH HHS R01 AR065183NIAMS NIH HHS RC1 AR058315NIAMS NIH HHS T32 AR007175
6 · The paper itself

Abstract

Killer cell immunoglobulin-like receptors (KIR) regulate immune responses in NK and CD8+ T cells

Indexed as

AllelesDNA Copy Number VariationsCase-Control StudiesEuropeGenetic Predisposition to DiseaseHLA-A AntigensHLA-B AntigensHumansLogistic ModelsNorth AmericaPolymorphism, Single NucleotidePsoriasisReceptors, KIR2DL2HLA-A AntigensHLA-B AntigensKIR2DL2 protein, humanReceptors, KIR2DL2autoimmunitygeneticsHLAimputationKIRpsoriasis

Identifiers

PMID34177931
PMCPMC8231283
OpenAlexW3172187461

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.