ArticleFrontiers in immunology2021
Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation.
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Beyond conventional immunosuppression: tailoring perioperative management protocols for clinical xenotransplantation.Clinical transplantation and research · 2026Review
- Cryopreservation Strategies to Improve Access to Organ Transplantation.Transplantation · 2026Review
- Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Review
- Mineralocorticoid receptor phase separation modulates cardiac preservation.Nature cardiovascular research · 2025Article
- Transplantation of a genetically modified porcine heart into a live human.Nature medicine · 2025Article
- Genetically engineered pig heart transplantation in non-human primates.Communications medicine · 2025Article
- Considerations for the use of porcine organ donation models in preclinical organ donor intervention research.Animal models and experimental medicine · 2024Review
- Progress in Orthotopic Pig Heart Transplantation in Nonhuman Primates.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Consensus statement on heart xenotransplantation in children: Toward clinical translation.The Journal of thoracic and cardiovascular surgery · 2023Article
- A Standardized Approach to Orthotopic (Life-supporting) Porcine Cardiac Xenotransplantation in a Nonhuman Primate Model.Transplantation · 2023Article
- Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report.Lancet (London, England) · 2023Article
- Milestones on the path to clinical pig organ xenotransplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Review
- The growth of xenotransplanted hearts can be reduced with growth hormone receptor knockout pig donors.The Journal of thoracic and cardiovascular surgery · 2023Article
- The road to the first FDA-approved genetically engineered pig heart transplantation into human.Xenotransplantation · 2022Article
- Strategies for Expanding Donors Pool in Heart Transplantation.Reviews in cardiovascular medicine · 2022Review
- The immunobiology and clinical use of genetically engineered porcine hearts for cardiac xenotransplantation.Nature cardiovascular research · 2022Article
- The first clinical pig heart transplant: Was IVIg or pig cytomegalovirus detrimental to the outcome?Xenotransplantation · 2022Review
- Evolution of Xenotransplantation as an Alternative to Shortage of Donors in Heart Transplantation.Cureus · 2022Review
- Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months.Xenotransplantation · 2022Article
- Autologous blood resuscitation for large animals in a research setting using the Hemafuse device: Preliminary data of device use for controlled and real-world hemorrhage.Frontiers in veterinary science · 2022Article
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Authors and funding
19 authors at 3 institutions in 2 countries.
Funding
Abstract
Background: Perioperative cardiac xenograft dysfunction (PCXD) describes a rapidly developing loss of cardiac function after xenotransplantation. PCXD occurs despite genetic modifications to increase compatibility of the heart. We report on the incidence of PCXD using static preservation in ice slush following crystalloid or blood-based cardioplegia versus continuous cold perfusion with XVIVO Methods: Baboons were weight matched to genetically engineered swine heart donors. Cardioplegia volume was 30 cc/kg by donor weight, with del Nido cardioplegia and the addition of 25% by volume of donor whole blood. Continuous perfusion was performed using an XVIVO Results: PCXD was observed in 5/8 that were preserved with crystalloid cardioplegia followed by traditional cold, static storage on ice. By comparison, when blood cardioplegia was used followed by cold, static storage, PCXD occurred in 1/3 hearts and only in 1/5 hearts that were induced with XHS blood cardioplegia followed by continuous perfusion. Survival averaged 17 hours in those with traditional preservation and storage, followed by 11.47 days and 15.03 days using blood cardioplegia and XHS+continuous preservation, respectively. Traditional preservation resulted in more inotropic support and higher average peak serum lactate 14.3±1.7 mmol/L compared to blood cardioplegia 3.6±3.0 mmol/L and continuous perfusion 3.5±1.5 mmol/L. Conclusion: Blood cardioplegia induction, alone or followed by XHS perfusion storage, reduced the incidence of PCXD and improved graft function and survival, relative to traditional crystalloid cardioplegia-slush storage alone.
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