Evidence map›Paper›PMID 34177905›Full record

ArticleFrontiers in immunology2021

Highly Sensitive Flow Cytometry Allows Monitoring of Changes in Circulating Immune Cells in Blood After Tdap Booster Vaccination.

Annieck M Diks, Indu Khatri, Liesbeth E M Oosten, Bas de Mooij, Rick J Groenland, Cristina Teodosio, Martin Perez-Andres, Alberto Orfao, Guy A M Berbers, Jaap Jan Zwaginga and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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  6. Applications of Flow Cytometry in Drug Discovery and Translational Research.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Annieck M DiksDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Indu KhatriDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Liesbeth E M OostenDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Bas de MooijDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Rick J GroenlandDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Cristina TeodosioDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Martin Perez-AndresCancer Research Centre (IBMCC, USAL-CSIC; CIBERONC CB16/12/00400), Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
Alberto OrfaoCancer Research Centre (IBMCC, USAL-CSIC; CIBERONC CB16/12/00400), Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.
Guy A M BerbersCenter for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, Netherlands.
Jaap Jan ZwagingaDepartment of Hematology, Leiden University Medical Center, Leiden, Netherlands.
Jacques J M van DongenDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Magdalena A BerkowskaDepartment of Immunology, Leiden University Medical Center, Leiden, Netherlands.
Leiden University Medical Center · NLCentro de Investigación del Cáncer · ESNational Institute for Public Health and the Environment · NLUniversidad de Salamanca · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antigen-specific serum immunoglobulin (Ag-specific Ig) levels are broadly used as correlates of protection. However, in several disease and vaccination models these fail to predict immunity. In these models, in-depth knowledge of cellular processes associated with protective versus poor responses may bring added value. We applied high-throughput multicolor flow cytometry to track over-time changes in circulating immune cells in 10 individuals following pertussis booster vaccination (Tdap, Boostrix

Indexed as

AdultAntibodies, BacterialAntigens, BacterialB-LymphocytesBordetella pertussisDiphtheria-Tetanus-Pertussis VaccineFemaleFlow CytometryHumansImmunity, CellularImmunity, HumoralImmunization, SecondaryImmunologic MemoryMaleMiddle AgedVaccinationAntibodies, BacterialAntigens, BacterialBoostrixDiphtheria-Tetanus-Pertussis Vaccinecorrelation networksflow cytometryimmune monitoringpertussis vaccineplasma cells

Identifiers

PMID34177905
PMCPMC8223751
OpenAlexW3171762519

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.