Evidence map›Paper›PMID 34177885›Full record

ArticleFrontiers in immunology2021

Alteration of Intestinal Microbiota Composition in Oral Sensitized C3H/HeJ Mice Is Associated With Changes in Dendritic Cells and T Cells in Mesenteric Lymph Nodes.

Cui Zhou, Ling-Ling Chen, Rui-Qi Lu, Wei-Wei Ma, Rong Xiao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  4. Regulatory effects ofFrontiers in immunology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Cui ZhouBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing, China.
Ling-Ling ChenNutritional Department, Handan First Hospital, Handan, China.
Rui-Qi LuSchool of Basic Medicine, Capital Medical University, Beijing, China.
Wei-Wei MaBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing, China.
Rong XiaoBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, Beijing, China.
Capital Medical University · CNHandan College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This research aimed to investigate the allergic reaction of C3H/HeJ mice after sensitization with ovalbumin (OVA) without any adjuvant and to analyze the association between intestinal microbiota and allergy-related immune cells in mesenteric lymph nodes (MLN). The allergic responses of C3H/HeJ mice orally sensitized with OVA were evaluated, and immune cell subsets in spleen and MLN and cytokines were also detected. The intestinal bacterial community structure was analyzed, followed by Spearman correlation analysis between changed gut microbiota species and allergic parameters. Sensitization induced a noticeable allergic response to the gavage of OVA without adjuvant. Increased levels of Th2, IL-4, CD103

Indexed as

Gastrointestinal MicrobiomeAnimalsBacteriaCytokinesDendritic CellsDisease Models, AnimalFecesFood HypersensitivityLymph NodesMesenteryMiceMice, Inbred C3HOvalbuminSpleenT-Lymphocytes, RegulatoryCytokinesOvalbumin16S rRNAClostridialesdendritic cellsintestinal microbiotaMollicutes_RF39OVA sensitizationregulation T cells

Identifiers

PMID34177885
PMCPMC8222730
OpenAlexW3166150650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.