ArticleFrontiers in endocrinology2021
Analysis of the Incidence of Euthyroid Sick Syndrome in Comprehensive Intensive Care Units and Related Risk Factors.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 30 citations in OpenAlex.
- Non-thyroidal Illness Syndrome and Clinical Outcomes in Critically Ill ICU Patients: A Prospective Cohort Study.Cureus · 2026Article
- Determinants of fatal outcome in septic shock patients with euthyroid sick syndrome.World journal of critical care medicine · 2026Article
- Ketogenic Diet and Thyroid Function: A Delicate Metabolic Balancing Act.Current issues in molecular biology · 2025Review
- Non-Thyroidal Illness Syndrome: A Predictor of Non-Invasive Ventilation Failure and Mortality in Critically Ill Patients.Medicina (Kaunas, Lithuania) · 2025Article
- Serum parameters and energy balance during the Yukon Arctic Ultra: a multistage ultramarathon in Arctic conditions.Frontiers in nutrition · 2025Article
- Low T3World journal of critical care medicine · 2024Article
- Authors' reply: clinical implication of thyroid status in patients with atrial fibrillation.Heart and vessels · 2024Article
- [Related factors of euthyroid sick syndrome in patients with sepsis].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Non-thyroidal Illness in Children with Congestive Heart FailureJournal of clinical research in pediatric endocrinology · 2024Article
- The Cross-sectional and Longitudinal Association Between Thyroid Function and Depression: A Population-Based Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Correlation between a low serum free triiodothyronine level and mortality of severe pulmonary tuberculosis patients.BMC infectious diseases · 2024Article
- Prognostic implications of thyroid disease in patients with atrial fibrillation.Heart and vessels · 2024Article
- Impact of thyroid hormones on predicting the occurrence of persistent inflammation, immunosuppression, and catabolism syndrome in patients with sepsis.Frontiers in endocrinology · 2024Observational
- The prevalence, hospitalization outcomes and risk factors of euthyroid sick syndrome in patients with diabetic ketosis/ketoacidosis.BMC endocrine disorders · 2023Article
- Association between dynamic fluctuations in triiodothyronine levels and prognosis among critically ill patients within comprehensive intensive care units.Frontiers in endocrinology · 2023Observational
- Thyroid hormone levels paradox in acute ischemic stroke.Translational neuroscience · 2023Article
- Transient low T3 syndrome in patients with COVID-19: a new window for prediction of disease severity.Frontiers in endocrinology · 2023Article
- Thyroid Diseases and Thyroid Asymptomatic Dysfunction in People Living With HIV.Infectious disease reports · 2022Review
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4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: A low concentration of plasma triiodothyronine (T3) indicates euthyroid sick syndrome (ESS), which could be associated with a poor outcome in patients in intensive care units (ICUs). This study evaluated the relationship between ESS and prognostic indicators in patients admitted to an ICU and examined the free T3 (FT3) cut-off points that could be associated with 28-day mortality. Methods: This prospective observational study included patients admitted to the ICU of The Third Hospital of Hebei Medical University between February and November 2018. Baseline variables and data on the occurrence of low FT3 were collected. The patients were divided into ESS (FT3 < 3.28 pmol/L) and non-ESS groups. The relationship between ESS and prognostic indicators in patients admitted to the ICU was evaluated, and the FT3 cut-off points that could be associated with 28-day mortality were examined. Results: Out of a total of 305 patients, 118 (38.7%) were in the ESS group. Levels of FT3 (P < 0.001) and FT4 (P = 0.001) were lower, while the 28-day mortality rate (P < 0.001) and hospitalization expenses in the ICU (P = 0.001) were higher in the ESS group. A univariable analysis identified ESS, FT3, free thyroxine (FT4)/FT3, the APACHE II score, the sequential organ failure (SOFA) score, the duration of mechanical ventilation, creatinine (CREA) levels, the oxygenation index (HGB), white blood cells, albumin (ALB) levels, age, and brain natriuretic peptide (BNP) levels as factors associated with 28-day mortality (all P < 0.05). The cut-off value of FT3 for 28-day mortality was 2.88 pmol/L, and the 28-day mortality rate and hospitalization expenses in the ICU were higher in patients with ESS. The syndrome was confirmed to be independently associated with 28-day mortality. Conclusion: This study determined the incidence of ESS in the comprehensive ICU to be 38.7%. APACHE II, SOFA, BNP, APTT, HGB, PLT, CREA, ALB, FT4, SBP, and DBP are closely related to ESS, while BNP, PLT, and ALB are independent risk factors for the syndrome.
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