ArticleFrontiers in neurology2021
Stimulation-Induced Side Effects of Deep Brain Stimulation in the Ventralis Intermedius and Posterior Subthalamic Area for Essential Tremor.
Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Risk factors and intervention of caregiver burden in Parkinson's disease: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Pooled it
- Deep Brain Stimulation of the Posterior Subthalamic Area and the Subthalamic Nucleus in Tremor-Dominant Parkinson's Disease: A Randomized, Crossover Trial.Movement disorders : official journal of the Movement Disorder Society · 2026Trial
- Deep brain stimulation of the medial geniculate body for refractory tinnitus: A feasibility study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Probabilistic mapping of tremor control and gait ataxia risk in deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Feasibility Pilot of the LaceUp Compression-Weight Sleeve for Essential Tremor.Bioengineering (Basel, Switzerland) · 2026Article
- AI-based discovery of functional boundaries in the human brain from intraoperative electrophysiology.medRxiv : the preprint server for health sciences · 2026Article
- Patient-Reported Feedback Suggests an Alternative Sweet Spot for Deep Brain Stimulation Programming in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- What factors influence the length of stay and readmission after deep brain stimulation surgery? a tertiary centre study.Acta neurochirurgica · 2026Article
- Surgical Treatment of Tremor Syndromes: A Guide to the Clinician.Movement disorders clinical practice · 2026Review
- Clinical utility of evoked potentials for programming subthalamic deep brain stimulation in Parkinsons disease.NPJ Parkinson's disease · 2026Review
- Apathy and Reduced Voluntary Activity in Older Adults with Parkinson's Disease: Mechanisms, Clinical Assessment, and Rehabilitation Implications.Clinical interventions in aging · 2026Review
- Multitarget neurostimulation of the deep brain: clinical opportunities, challenges, and emerging technologies.Journal of neural engineering · 2025Review
- Dissociation between Simple and Complex Speech Motor Tasks within the Bilateral Motor Thalamus.eNeuro · 2025Article
- Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation.Nature biomedical engineering · 2025Review
- A case report: combined posterior subthalamic area and globus pallidus internus deep brain stimulation in Parkinson's disease.Frontiers in human neuroscience · 2025Article
- Bilateral Deep Brain Stimulation of Posterior Subthalamic Area in Patient with Spinocerebellar Ataxia Type 12.Movement disorders clinical practice · 2024Article
- Article
- Management of essential tremor deep brain stimulation-induced side effects.Frontiers in human neuroscience · 2024Review
- An Eye on the First Surgical Side: Appreciating the Potential Impacts of a Second DBS Lead on Ipsilateral Symptoms.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Deep brain stimulation of the subthalamic nucleus in severe Parkinson's disease: relationships between dual-contact topographic setting and 1-year worsening of speech and gait.Acta neurochirurgica · 2023Observational
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep brain stimulation (DBS) targeting the ventralis intermedius (VIM) nucleus of the thalamus and the posterior subthalamic area (PSA) has been shown to be an effective treatment for essential tremor (ET). The aim of this study was to compare the stimulation-induced side effects of DBS targeting the VIM and PSA using a single electrode. Patients with medication-refractory ET who underwent DBS electrode implantation between July 2011 and October 2020 using a surgical technique that simultaneously targets the VIM and PSA with a single electrode were enrolled in this study. A total of 93 patients with ET who had 115 implanted DBS electrodes (71 unilateral and 22 bilateral) were enrolled. The Clinical Rating Scale for Tremor (CRST) subscores improved from 20.0 preoperatively to 4.3 (78.5% reduction) at 6 months, 6.3 (68.5% reduction) at 1 year, and 6.5 (67.5% reduction) at 2 years postoperation. The best clinical effect was achieved in the PSA at significantly lower stimulation amplitudes. Gait disturbance and clumsiness in the leg was found in 13 patients (14.0%) upon stimulation of the PSA and in significantly few patients upon stimulation of the VIM (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.