ArticleThe Journal of cell biology1988
Two classes of actin microfilaments are associated with the inner cytoskeleton of axons.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 98 citations in OpenAlex.
- Linking neuron-axon-synapse architecture to white matter vasculature using high-resolution multimodal MRI in primate brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Ribose-induced advanced glycation end products reduce the lifespan in Drosophila melanogaster by changing the redox state and down-regulating the Sirtuin genes.Biogerontology · 2024Article
- The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration.Molecular neurobiology · 2024Review
- Finding order in slow axonal transport.Current opinion in neurobiology · 2020Review
- Cytoskeletal organization of axons in vertebrates and invertebrates.The Journal of cell biology · 2020Article
- The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology.Neural development · 2019Review
- The nano-architecture of the axonal cytoskeleton.Nature reviews. Neuroscience · 2017Review
- Axonal actin in action: Imaging actin dynamics in neurons.Methods in cell biology · 2016Article
- A dynamic formin-dependent deep F-actin network in axons.The Journal of cell biology · 2015Article
- Drag of the cytosol as a transport mechanism in neurons.Biophysical journal · 2014Article
- Classification of axonal subtypes based on cytoskeletal components.Cell health and cytoskeleton · 2014Article
- Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon.Physical biology · 2012Article
- The axonal transport of mitochondria.Journal of cell science · 2012Review
- Distortion of axonal cytoskeleton: an early sign of glaucomatous damage.Investigative ophthalmology & visual science · 2011Article
- Altered F-actin distribution in retinal nerve fiber layer of a rat model of glaucoma.Experimental eye research · 2009Article
- Myosin Va increases the efficiency of neurofilament transport by decreasing the duration of long-term pauses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Actin-ATP hydrolysis is a major energy drain for neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain.Molecular biology of the cell · 1999Article
- Association of actin filaments with axonal microtubule tracts.Journal of neurocytology · 1999Article
- Actin-based motility of isolated axoplasmic organelles.Cell motility and the cytoskeleton · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution and length of actin microfilaments (MF) was determined in axoplasm extruded from the giant axons of the squid (Loligo pealeii). Extruded axoplasm that was separated from the axonal cortex contains approximately 92% of the total axonal actin, and 60% of this actin is polymerized (Morris, J., and R. Lasek. 1984. J. Cell Biol. 98:2064-2076). Localization of MF with rhodamine-phalloidin indicated that the MF were organized in fine columns oriented longitudinally within the axoplasm. In the electron microscope, MF were surrounded by a dense matrix and they were associated with the microtubule domains of the axoplasm. The surrounding matrix tended to obscure the MF which may explain why MF have rarely been recognized before in the inner regions of the axon. The axoplasmic MF are relatively short (number average length of 0.55 micron). Length measurements of MF prepared either in the presence or absence of the actin-filament stabilizing drug phalloidin indicate that axoplasm contains two populations of MF: stable MF (number average length of 0.79 micron) and metastable MF (number average length of 0.41 micron). Although individual axonal MF are much shorter than axonal microtubules, the combined length of the total MF is twice that of the total microtubules. Apparently, these numerous short MF have an important structural role in the architecture of the inner axonal cytoskeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.