ArticleFrontiers in psychiatry2021
Physical Activity Reduces Clinical Symptoms and Restores Neuroplasticity in Major Depression.
Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Effects of exercise on cognitive function in patients with depression: a three-level meta-analysis with dose-response and exploratory mediation analyses.The international journal of behavioral nutrition and physical activity · 2026Pooled it
- The Effects of Exercise on Inhibitory Function Interventions for Patients With Major Depressive Disorder (MDD): A Systematic Review and Meta-Analysis.Brain and behavior · 2025Pooled it
- Effects of Physical Exercise on Executive Function in Adults with Depression: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Comparative Effectiveness of Multiple Exercise Interventions in the Treatment of Mental Health Disorders: A Systematic Review and Network Meta-Analysis.Sports medicine - open · 2022Pooled it
- Physical and Emotional Interventions in Modulating Neuroplasticity: A Narrative Review of Recent Evidence.Cureus · 2025Review
- The effect of an app-based health intervention on somatic symptoms among employees of the DHL Group: a longitudinal pilot study.International archives of occupational and environmental health · 2025Article
- Impact of Pediatric Leukemia on Maternal Anxiety, Depression, Sleep Quality, and Physical Activity.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Digital measures of activity and motivation impact depression and anxiety in the real world.NPJ digital medicine · 2025Article
- Physical Activity and Depression in Breast Cancer Patients: Mechanisms and Therapeutic Potential.Current oncology (Toronto, Ont.) · 2025Review
- Relationships between depression, anxiety, and motivation in the real-world: Effects of physical activity and screentime.medRxiv : the preprint server for health sciences · 2024Article
- Acute effects of aerobic exercise on corticomotor plasticity in individuals with and without depression.Journal of psychiatric research · 2024Article
- From movement to motivation: a proposed framework to understand the antidepressant effect of exercise.Translational psychiatry · 2024Review
- Preventive exercise and physical rehabilitation promote long-term potentiation-like plasticity expression in patients with multiple sclerosis.European journal of neurology · 2024Article
- Effects and neural mechanisms of different physical activity on major depressive disorder based on cerebral multimodality monitoring: a narrative review.Frontiers in human neuroscience · 2024Review
- Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior.Clinical nutrition research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is the most common mental disorder and deficits in neuroplasticity are discussed as one pathophysiological mechanism. Physical activity (PA) enhances neuroplasticity in healthy subjects and improves clinical symptoms of MDD. However, it is unclear whether this clinical effect of PA is due to restoring deficient neuroplasticity in MDD. We investigated the effect of a 3-week PA program applied on clinical symptoms, motor excitability and plasticity, and on cognition in patients with MDD (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.