Evidence map›Paper›PMID 34177598›Full record

ArticleFrontiers in pharmacology2021

Role of Common Genetic Variants for Drug-Resistance to Specific Anti-Seizure Medications.

Stefan Wolking, Ciarán Campbell, Caragh Stapleton, Mark McCormack, Norman Delanty, Chantal Depondt, Michael R Johnson, Bobby P C Koeleman, Roland Krause, Wolfram S Kunz and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Association between Genetic Polymorphism ofMedicina (Kaunas, Lithuania) · 2024
    Article
  7. Article
  8. The fruit flyFrontiers in pharmacology · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature).International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 7 countries.

Stefan WolkingNeurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Ciarán CampbellDepartment of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Caragh StapletonDepartment of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Mark McCormackDepartment of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Norman DelantyDepartment of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Chantal DepondtDepartment of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Michael R JohnsonDivision of Brain Sciences, Imperial College Faculty of Medicine, London, United Kingdom.
Bobby P C KoelemanDepartment of Genetics, University Medical Center Utrecht, Utrecht, Netherlands.
Roland KrauseLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Wolfram S KunzInstitute of Experimental Epileptology and Cognition Research and Department of Epileptology, University of Bonn, Bonn, Germany.
Anthony G MarsonDepartment of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Josemir W SanderDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom.
Graeme J SillsSchool of Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Pasquale StrianoIRCCS "G. Gaslini" Institute, Genova, Italy.
Federico ZaraIRCCS "G. Gaslini" Institute, Genova, Italy.
Sanjay M SisodiyaDepartment of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom.
Gianpiero L CavalleriDepartment of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Holger LercheNeurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Royal College of Surgeons in Ireland · IEEpilepsy Society · GBErasmus Hospital · BEHertie Institute for Clinical Brain Research · DEImperial College London · GBIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Giannina Gaslini · ITScience Foundation Ireland · IEUniversity Medical Center Utrecht · NLUniversity of Bonn · DEUniversity of Glasgow · GBUniversity of Liverpool · GBUniversity of Luxembourg · LUUniversity of Tübingen · DE

Funding

Medical Research Council MR/S02638X/1
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

anti-seizure medication (ASM)drug-resistant epilepsiesGWASpolygenic risk score (PRS)single nucelotide polymorphisms

Identifiers

PMID34177598
PMCPMC8220970
OpenAlexW3168701222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.