ArticleFrontiers in aging neuroscience2021
Interactions Between Aging and Alzheimer's Disease on Structural Brain Networks.
Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Network-specific metabolic cost of functional connectivity in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Alzheimer's Disease Detection Using Combined EEG Source Connectivity and Microstate Features.Brain sciences · 2026Article
- Topological turning points across the human lifespan.Nature communications · 2025Article
- Emerging Role of Mesenchymal Stromal Cell and Exosome Therapies in Treating Cognitive Impairment.Pharmaceutics · 2025Review
- Sex-specific brain morphological and network differences in patients showing Parkinson's disease with and without possible rapid eye movement sleep behavior disorder.Frontiers in neurology · 2025Article
- Caudal and Thalamic Segregation in White Matter Brain Network Communities in Alzheimer's Disease Population.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2024Article
- Voxel-Wise Fusion of 3T and 7T Diffusion MRI Data to Extract more Accurate Fiber Orientations.Brain topography · 2024Article
- Article
- Predicting Alzheimer's progression in MCI: a DTI-based white matter network model.BMC medical imaging · 2024Article
- Age-related differences in structural and resting-state functional brain network organization across the adult lifespan: A cross-sectional study.Aging brain · 2024Article
- Physical fitness, cognition, and structural network efficiency of brain connections across the lifespan.Neuropsychologia · 2023Article
- Age-Related Modifications of Electroencephalogram Coherence in Mice Models of Alzheimer's Disease and Amyotrophic Lateral Sclerosis.Biomedicines · 2023Article
- Review
- Compensatory Mechanisms in Early Alzheimer's Disease and Clinical Setting: The Need for Novel Neuropsychological Strategies.Journal of Alzheimer's disease reports · 2023Review
- The Characteristics of Entorhinal Cortex Functional Connectivity in Alzheimer's Disease Patients with Depression.Current Alzheimer research · 2022Article
- Alzheimer's disease is an inherent, natural part of human brain aging: an integrated perspective.Free neuropathology · 2022Article
- Alteration in cerebral cortex thickness and structural covariance networks in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).Frontiers in neurologyArticle
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Authors and funding
8 authors.
Funding
Abstract
Normative aging and Alzheimer's disease (AD) propagation alter anatomical connections among brain parcels. However, the interaction between the trajectories of age- and AD-linked alterations in the topology of the structural brain network is not well understood. In this study, diffusion-weighted magnetic resonance imaging (MRI) datasets of 139 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database were used to document their structural brain networks. The 139 participants consist of 45 normal controls (NCs), 37 with early mild cognitive impairment (EMCI), 27 with late mild cognitive impairment (LMCI), and 30 AD patients. All subjects were further divided into three subgroups based on their age (56-65, 66-75, and 71-85 years). After the structural connectivity networks were built using anatomically-constrained deterministic tractography, their global and nodal topological properties were estimated, including network efficiency, characteristic path length, transitivity, modularity coefficient, clustering coefficient, and betweenness. Statistical analyses were then performed on these metrics using linear regression, and one- and two-way ANOVA testing to examine group differences and interactions between aging and AD propagation. No significant interactions were found between aging and AD propagation in the global topological metrics (network efficiency, characteristic path length, transitivity, and modularity coefficient). However, nodal metrics (clustering coefficient and betweenness centrality) of some cortical parcels exhibited significant interactions between aging and AD propagation, with affected parcels including left superior temporal, right pars triangularis, and right precentral. The results collectively confirm the age-related deterioration of structural networks in MCI and AD patients, providing novel insight into the cross effects of aging and AD disorder on brain structural networks. Some early symptoms of AD may also be due to age-associated anatomic vulnerability interacting with early anatomic changes associated with AD.
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