ArticleFrontiers in human neuroscience2021
Disrupted Structural Brain Connectome Is Related to Cognitive Impairment in Patients With Ischemic Leukoaraiosis.
Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Impaired white matter functional networks topology changed with white matter hyperintensities burden and relationship to cognition.Brain imaging and behavior · 2026Article
- Long-range connections damage in white matter hyperintensities affects information processing speed.Brain communications · 2024Article
- Clinical and cognitive correlates tractography analysis in patients with white matter hyperintensity of vascular origin.Frontiers in neuroscience · 2023Article
- Structural disconnectome mapping of cognitive function in poststroke patients.Brain and behavior · 2022Article
- Breathing Exercises for Improving Cognitive Function in Patients with Stroke.Journal of clinical medicine · 2022Review
- Association between Changes in White Matter Microstructure and Cognitive Impairment in White Matter Lesions.Brain sciences · 2022Article
- Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment.Frontiers in neurology · 2022Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
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Abstract
Ischemic leukoaraiosis (ILA) is related to cognitive impairment and vascular dementia in the elderly. One possible mechanism could be the disruption of white matter (WM) tracts and network function that connect distributed brain regions involved in cognition. The purpose of this study was to investigate the relationship between structural connectome and cognitive functions in ILA patients. A total of 89 patients with ILA (Fazekas score ≥ 3) and 90 healthy controls (HCs) underwent comprehensive neuropsychological examinations and diffusion tensor imaging scans. The tract-based spatial statistics approach was employed to investigate the WM integrity. Graph theoretical analysis was further applied to construct the topological architecture of the structural connectome in ILA patients. Partial correlation analysis was used to investigate the relationships between network measures and cognitive performances in the ILA group. Compared with HCs, the ILA patients showed widespread WM integrity disruptions. The ILA group displayed increased characteristic path length (
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