ArticleFrontiers in neuroscience2021
Whole-Brain Imaging of Subvoxel T1-Diffusion Correlation Spectra in Human Subjects.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- MultidimensionalbioRxiv : the preprint server for biology · 2026Article
- Informed Dictionary-Guided Monte Carlo Inversion for Robust and Reproducible Multidimensional MRI.Magnetic resonance in medicine · 2026Article
- Multidimensional correlation magnetic resonance imaging in low- and middle-income countries: opportunities and barriers to equitable deployment.Frontiers in public health · 2026Review
- Relaxation-Selective Intravoxel Incoherent Motion Imaging of Microvascular Perfusion and Fluid Compartments in the Human Choroid Plexus.NMR in biomedicine · 2025Article
- Maximum-entropy and subspace methods for high-resolution relaxation-diffusion distribution estimation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The Subcortical Atlas of the Marmoset ("SAM") monkey based on high-resolution MRI and histology.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The Subcortical Atlas of the Marmoset ("SAM") monkey based on high-resolution MRI and histology.bioRxiv : the preprint server for biology · 2024Article
- Direct segmentation of cortical cytoarchitectonic domains using ultra-high-resolution whole-brain diffusion MRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A novel framework for in-vivo diffusion tensor distribution MRI of the human brain.NeuroImage · 2023Article
- Data inversion of multi-dimensional magnetic resonance in porous media.Magnetic resonance letters · 2023Article
- Adult lifespan maturation and degeneration patterns in gray and white matter: A mean apparent propagator (MAP) MRI study.Neurobiology of aging · 2023Article
- Mapping astrogliosis in the individual human brain using multidimensional MRI.Brain : a journal of neurology · 2023Article
- In Vivo Myelin Water Quantification Using Diffusion-Relaxation Correlation MRI: A Comparison of 1D and 2D Methods.Applied magnetic resonance · 2023Article
- COnstrained Reference frame diffusion TEnsor Correlation Spectroscopic (CORTECS) MRI: A practical framework for high-resolution diffusion tensor distribution imaging.Frontiers in neuroscience · 2022Article
- High-resolution mapping and digital atlas of subcortical regions in the macaque monkey based on matched MAP-MRI and histology.NeuroImage · 2021Article
- Multidimensional MRI for Characterization of Subtle Axonal Injury Accelerated Using an Adaptive Nonlocal Multispectral Filter.Frontiers in physics · 2021Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T1 relaxation and water mobility generate eloquent MRI tissue contrasts with great diagnostic value in many neuroradiological applications. However, conventional methods do not adequately quantify the microscopic heterogeneity of these important biophysical properties within a voxel, and therefore have limited biological specificity. We describe a new correlation spectroscopic (CS) MRI method for measuring how T1 and mean diffusivity (MD) co-vary in microscopic tissue environments. We develop a clinical pulse sequence that combines inversion recovery (IR) with single-shot isotropic diffusion encoding (IDE) to efficiently acquire whole-brain MRIs with a wide range of joint T1-MD weightings. Unlike conventional diffusion encoding, the IDE preparation ensures that all subvoxel water pools are weighted by their MDs regardless of the sizes, shapes, and orientations of their corresponding microscopic diffusion tensors. Accordingly, IR-IDE measurements are well-suited for model-free, quantitative spectroscopic analysis of microscopic water pools. Using numerical simulations, phantom experiments, and data from healthy volunteers we demonstrate how IR-IDE MRIs can be processed to reconstruct maps of two-dimensional joint probability density functions, i.e., correlation spectra, of subvoxel T1-MD values.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.