Evidence map›Paper›PMID 34177442›Full record

ArticleFrontiers in neuroscience2021

Large-Area Photoreceptor Degeneration Model in Rabbits by Photocoagulation and Oxidative Stress in the Retina.

Zhexuan Wang, Chenli Feng, Ruyi Yang, Tingting Liu, Yin Chen, Aihua Chen, Biao Yan, Yuanzhi Yuan, Jiayi Zhang

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Outer Retinal Cell Replacement: Putting the Pieces Together.Translational vision science & technology · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Zhexuan WangState Key Laboratory of Medical Neurobiology, Department of Ophthalmology, MOE Frontiers Center for Brain Science, Zhongshan Hospital, Institute for Brain Science, Fudan University, Shanghai, China.
Chenli FengState Key Laboratory of Medical Neurobiology, Department of Ophthalmology, MOE Frontiers Center for Brain Science, Zhongshan Hospital, Institute for Brain Science, Fudan University, Shanghai, China.
Ruyi YangState Key Laboratory of Medical Neurobiology, Department of Ophthalmology, MOE Frontiers Center for Brain Science, Zhongshan Hospital, Institute for Brain Science, Fudan University, Shanghai, China.
Tingting LiuDepartment of Ophthalmology, Eye and Ent Hospital of Fudan University, Shanghai, China.
Yin ChenKey Laboratory of Brain Functional Genomics, Primate Research Center, East China Normal University, Shanghai, China.
Aihua ChenKey Laboratory of Brain Functional Genomics, Primate Research Center, East China Normal University, Shanghai, China.
Biao YanState Key Laboratory of Medical Neurobiology, Department of Ophthalmology, MOE Frontiers Center for Brain Science, Zhongshan Hospital, Institute for Brain Science, Fudan University, Shanghai, China.
Yuanzhi YuanState Key Laboratory of Medical Neurobiology, Department of Ophthalmology, MOE Frontiers Center for Brain Science, Zhongshan Hospital, Institute for Brain Science, Fudan University, Shanghai, China.
Jiayi ZhangState Key Laboratory of Medical Neurobiology, Department of Ophthalmology, MOE Frontiers Center for Brain Science, Zhongshan Hospital, Institute for Brain Science, Fudan University, Shanghai, China.
Zhongshan Hospital · CNEast China Normal University · CNEye & ENT Hospital of Fudan University · CNState Key Laboratory of Medical Neurobiology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photocoagulation is used for the treatment of retinal ischemic disease. However, due to the invasive nature of photocoagulation and variety of melanin concentrations between individuals, it is challenging to avoid damaging the adjacent photoreceptors and inducing several side effects. Previous studies indicate the role of laser power, duration, and spot size on retinal lesions, but the effect of interspot distance of the laser pulses needs to be considered in panretinal photocoagulation. In this study, we examine different parameters of photocoagulation on lesions of the retina in rabbit, finding that the lesion level of the outer nuclear layer of the retina depended on the pulse duration and laser spot size, and decreasing interspot distance could completely abolish the photoreceptor layer. The degeneration of the photoreceptor by photocoagulation occurred in 24 h and was not restored afterward. We then conducted panretinal photocoagulation in rabbit and found that oxidative stress was decreased in the inner nuclear layer of the retina, and pupillary light reflex and ERG signals were impaired. Our study could provide a rabbit model to explore the mechanism of photoreceptor degeneration and therapies for the side effects after photocoagulation.

Indexed as

electroretinographylight pupillary reflexoxidative stressphotocoagulationrabbit model

Identifiers

PMID34177442
PMCPMC8222581
OpenAlexW3171142426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.