Evidence map›Paper›PMID 34177088›Full record

ArticleJournal of the ASEAN Federation of Endocrine Societies2021

Calcium, Vitamin D, and Bone Derangement in Nephrotic Syndrome.

Samantha Peiling Yang, Lizhen Ong, Tze Ping Loh, Horng Ruey Chua, Cassandra Tham, Khoo Chin Meng, Lim Pin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the ASEAN Federation of Endocrine Societies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Samantha Peiling YangEndocrinology Division, Department of Medicine, National University Hospital, Singapore.
Lizhen OngDepartment of Laboratory Medicine, National University Hospital, Singapore.
Tze Ping LohDepartment of Laboratory Medicine, National University Hospital, Singapore.
Horng Ruey ChuaNephrology Division, Department of Medicine, National University Hospital, Singapore.
Cassandra ThamEndocrinology Division, Yong Loo Lin School of Medicine, Singapore.
Khoo Chin MengEndocrinology Division, Department of Medicine, National University Hospital, Singapore.
Lim PinEndocrinology Division, Department of Medicine, National University Hospital, Singapore.
National University of Singapore · SGNational University Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDerangement in calcium homeostasis is common in nephrotic syndrome (NS). It is postulated that low serum total calcium and vitamin D levels are due to loss of protein-bound calcium and vitamin D. It is unclear if free calcium and free vitamin D levels are truly low. The guideline is lacking with regards to calcium and vitamin D supplementation in NS. This study aims to examine calcium and vitamin D homeostasis and bone turnover in NS to guide practice in calcium and vitamin D levels supplementation. METHODOLOGY: This is a prospective pilot study of ten patients diagnosed with NS, and eight healthy controls. Calcium, vitamin D, and bone turnover-related analytes were assessed at baseline, partial and complete remission in NS patients and in healthy controls.

resultsNS patients had low free and total serum calcium, low total 25(OH)D, normal total 1,25(OH)D levels and lack of parathyroid hormone response. With remission of disease, serum calcium and vitamin D metabolites improved. However, nephrotic patients who do not attain complete disease remission continue to have low 25(OH)D level.

conclusionIn this study, the vitamin D and calcium derangement observed at nephrotic syndrome presentation trended towards normalisation in remission. This suggested calcium and vitamin D replacement may not be indicated in early-phase nephrotic syndrome but may be considered in prolonged nephrotic syndrome.

Indexed as

bone losshypocalcaemiaimmune-mediated nephrotic syndromeVitamin D deficiency

Identifiers

PMID34177088
PMCPMC8214354
OpenAlexW3157922564

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.