Evidence map›Paper›PMID 34177078›Full record

ArticleJournal of lightwave technology : a joint IEEE/OSA publication2021

Optofluidic Flow-Through Biosensor Sensitivity - Model and Experiment.

Joel G Wright, Md Nafiz Amin, Gopikrishnan G Meena, Holger Schmidt, Aaron R Hawkins

Abstract read
In one paragraph

Article in Journal of lightwave technology : a joint IEEE/OSA publication, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joel G WrightDepartment of Electrical and Computer Engineering, Brigham Young University, Provo, UT, 84602, USA.
Md Nafiz AminSchool of Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Gopikrishnan G MeenaSchool of Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Holger SchmidtSchool of Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Aaron R HawkinsDepartment of Electrical and Computer Engineering, Brigham Young University, Provo, UT, 84602, USA.

Funding

Multiplexed, Non-Amplified, Nucleic Acid-Based Identification of Multidrug Resistant Pathogens Using an Integrated Optofluidic PlatformR01AI116989 · NIAID · BRIGHAM YOUNG UNIVERSITY · PI HAWKINS, AARON R., PITT, WILLIAM G · 2015 to 2019
$5.4M
Nanopore-based multi-target analysis of Zika virus infectionR01EB028608 · NIBIB · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SCHMIDT, HOLGER · 2019 to 2022
$2.7M
NIAID NIH HHS R01 AI116989NIBIB NIH HHS R01 EB028608
6 · The paper itself

Abstract

We present a model and simulation for predicting the detected signal of a fluorescence-based optical biosensor built from optofluidic waveguides. Typical applications include flow experiments to determine pathogen concentrations in a biological sample after tagging relevant DNA or RNA sequences. An overview of the biosensor geometry and fabrication processes is presented. The basis for the predictive model is also outlined. The model is then compared to experimental results for three different biosensor designs. The model is shown to have similar signal statistics as physical tests, illustrating utility as a pre-fabrication design tool and as a predictor of detection sensitivity.

Indexed as

Anti-resonant reflecting optical waveguides (ARROW)integrated waveguidesmodel designoptofluidicspredictive simulation

Identifiers

PMID34177078
PMCPMC8224397

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.