Evidence map›Paper›PMID 34176710›Full record

ArticleNutrition, metabolism, and cardiovascular diseases : NMCD2021

New-onset vegetarian diet shows differences in fatty acid metabolites in European American and African American women.

Naomi C Wang, Minoo Bagheri, Timothy Olszewski, Katie A Friese, Holly M Smith, Michelle E Robles, Chuan Wang, Andrew Brooks, Seth R Bordenstein, Jane F Ferguson and 1 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Naomi C WangVanderbilt University Medical Center, Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, USA.
Minoo BagheriVanderbilt University Medical Center, Department of Medicine, Division of Cardiology Medicine, USA.
Timothy OlszewskiVanderbilt University Medical Center, Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, USA.
Katie A FrieseHarborview Medical Center, Seattle, WA, USA.
Holly M SmithVanderbilt University Medical Center, Department of Medicine, Division of Cardiology Medicine, USA.
Michelle E RoblesVanderbilt University Medical Center, Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, USA.
Chuan WangVanderbilt University Medical Center, Department of Medicine, Division of Cardiology Medicine, USA.
Andrew BrooksStanford University, School of Medicine, Department of Genetics, USA.
Seth R BordensteinVanderbilt University, College of Arts and Sciences, Department of Biological Sciences, USA.
Jane F FergusonVanderbilt University Medical Center, Department of Medicine, Division of Cardiology Medicine, USA.
Heidi J SilverVanderbilt University Medical Center, Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, USA. Electronic address: heidi.j.silver@vumc.org.
Vanderbilt University Medical Center · USFlorida State University · USHarborview Medical Center · USStanford University · USVA Tennessee Valley Healthcare System · US

Funding

Determinants of alpha-aminoadipic acid (2-AAA) and relationship to diabetesR01DK117144 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FERGUSON, JANE F · 2018 to 2022
$2.5M
Gut Bacteriophage Correspondence with Inflammation and Clinical Dietary InterventionsF32DK126287 · NIDDK · STANFORD UNIVERSITY · PI BROOKS, ANDREW WALLACE · 2021 to 2023
$205k
NIDDK NIH HHS F32 DK126287NIDDK NIH HHS R01 DK117144
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe type of fat consumed in animal-based western diets, typically rich in the saturated fat palmitate, has been implicated in cardiometabolic disease risk. In contrast, the most abundant mono- and polyunsaturated fats, more typical in a vegetarian or plant-based diet, potentiate less deleterious effects. This study determined differences in plasma and urine metabolites when switching from omnivorous to vegetarian diet, including metabolites involved in fatty acid utilization. METHODS AND

resultsA prospective cohort of 38 European (EA) and African American (AA) omnivorous females were matched by age (25.7 ± 5.3y) and BMI (22.4 ± 1.9 kg/m

conclusionThese data suggest improvements in fatty acid metabolism (oxidation vs storage), a key factor in energy homeostasis, may be promoted rapidly by adoption of a vegetarian (plant-based) diet. Mechanistic differences in response to diet interventions must be understood to effectively provide protection against the widespread development of obesity and cardiometabolic disease in population subgroups, such as AA women.

Indexed as

Energy MetabolismWhite PeopleAdultBiomarkersBlack or African AmericanChromatography, High Pressure LiquidDiet, HealthyDiet, VegetarianFatty AcidsFeeding BehaviorFemaleHumansMetabolomeMetabolomicsOxidation-ReductionProspective StudiesBiomarkersFatty AcidsDietFatty acidMetabolomicsPlant-basedVegetarian

Identifiers

PMID34176710
PMCPMC10317312
OpenAlexW3170659009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.