Evidence map›Paper›PMID 34176414›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer.

Wagdy M Eldehna, Rofaida Salem, Zainab M Elsayed, Tarfah Al-Warhi, Hamada R Knany, Rezk R Ayyad, Thamer Bin Traiki, Maha-Hamadien Abdulla, Rehan Ahmad, Hatem A Abdel-Aziz and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 40 citations in OpenAlex.

  1. Discovery of novel anti-RSC advances · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Development of New Pyrazolo [3,4-Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Wagdy M EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Rofaida SalemDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Zainab M ElsayedScientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Tarfah Al-WarhiDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Hamada R KnanyDepartment of Pharmacognosy, College of Pharmacy, Mansoura University, Mansoura, Egypt.
Rezk R AyyadDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Thamer Bin TraikiColorectal Research Chair, Department of Surgery, King Khalid University Hospital, King Saud University College of Medicine, Riyadh, Saudi Arabia.
Maha-Hamadien AbdullaColorectal Research Chair, Department of Surgery, King Khalid University Hospital, King Saud University College of Medicine, Riyadh, Saudi Arabia.
Rehan AhmadColorectal Research Chair, Department of Surgery, King Khalid University Hospital, King Saud University College of Medicine, Riyadh, Saudi Arabia.
Hatem A Abdel-AzizDepartment of Applied Organic Chemistry, National Research Center, Dokki, Giza, Egypt.
Radwan El-HaggarPharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Kafrelsheikh University · EGKing Khalid University Hospital · SAAl-Azhar University · EGHelwan University · EGKing Saud University · SAMansoura University · EGNational Research Centre · EGPrincess Nourah bint Abdulrahman University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates (

Indexed as

Antineoplastic AgentsApoptosisBenzofuransCell Line, TumorCell ProliferationColonic NeoplasmsDrug DevelopmentDrug Screening Assays, AntitumorHumansIsatinMolecular StructureProto-Oncogene Proteins c-bcl-2Antineoplastic AgentsBCL2 protein, humanbenzofuranBenzofuransIsatinProto-Oncogene Proteins c-bcl-2Bcl2 inhibitorsBenzofuran hydrazideCleaved PARPColon cancerIsatin

Identifiers

PMID34176414
PMCPMC8245078
OpenAlexW3174684496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.