Evidence map›Paper›PMID 34176381›Full record

ArticleDrug delivery2021

Prodrug-based nano-delivery strategy to improve the antitumor ability of carboplatin

Tingting Lang, Nuannuan Li, Jing Zhang, Yi Li, Rong Rong, Yuanlei Fu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tingting LangDepartment of Pharmaceutics, Yantai University, Yantai, PR China.ORCID https://orcid.org/0000-0001-6403-5243
Nuannuan LiDepartment of Pharmaceutics, Yantai University, Yantai, PR China.
Jing ZhangDepartment of Pharmaceutics, Binzhou Medical University, Yantai, PR China.
Yi LiKey Laboratory of Nanomedicine & Advanced Preparations, Yantai Institute of Materia Medica, Yantai, PR China.
Rong RongKey Laboratory of Nanomedicine & Advanced Preparations, Yantai Institute of Materia Medica, Yantai, PR China.
Yuanlei FuDepartment of Pharmaceutics, Yantai University, Yantai, PR China.
Binzhou Medical University · CNYantai Institute of Coastal Zone Research · CNYantai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy plays a major role in the treatment of cancer, but it still has great limitations in anti-tumor effect. Carboplatin (CAR) is the first-line drug in the treatment of non-small cell lung cancer, but the therapeutic effect is demonstrated weak. Therefore, we modified CAR with hexadecyl chain and polyethylene glycol, so as to realize its liposolubility and PEGylation. The synthesized amphiphilic CAR prodrugs could self-assemble into polymer micelles in water with an average particle size about 11.8 nm and low critical micelles concentration (0.0538 mg·mL

Indexed as

AnimalsCarboplatinCell Line, TumorCell SurvivalChemistry, PharmaceuticalDrug CarriersDrug LiberationFemaleMiceMicellesMice, NudeNanoparticlesParticle SizePolyethylene GlycolsProdrugsRandom AllocationCarboplatinDrug CarriersMicellesPolyethylene GlycolsProdrugsanti-tumor effectCarboplatinnano-delivery systemprodrugself-assembled micelles

Identifiers

PMID34176381
PMCPMC8238065
OpenAlexW3174479352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.