Evidence map›Paper›PMID 34176285›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Predictors of the Pressor Response to the Norepinephrine Transporter Inhibitor, Atomoxetine, in Neurogenic Orthostatic Hypotension.

Cyndya A Shibao, Jose-Alberto Palma, Jorge E Celedonio, Jose Martinez, Horacio Kaufmann, Italo Biaggioni

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Atomoxetine on neurogenic orthostatic hypotension: a randomized, double-blind, placebo-controlled crossover trial.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Trial
  2. Cardiovascular autonomic failure correlates with cutaneous autonomic denervation in PD and MSA.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  3. Review
  4. Orthostatic hypotension in Parkinson's disease: therapeutic considerations.Therapeutic advances in neurological disorders · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Mast cell activation syndrome: An up-to-date review of literature.World journal of clinical pediatrics · 2024
    Review
  9. Article
  10. Review
  11. Review
  12. The 2021 Nobel Prize in Medicine and its relevance to autonomic medicine-and other updates on recent autonomic research.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  13. Inhibition of the norepinephrine transporter to treat neurogenic orthostatic hypotension: is this the end of the story?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Cyndya A ShibaoVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (C.A.S., J.E.C., I.B.).
Jose-Alberto PalmaDysautonomia Center, Department of Neurology, NYU Langone Medical Center, NY (J.-A.P., J.M., H.K.).
Jorge E CeledonioVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (C.A.S., J.E.C., I.B.).
Jose MartinezDysautonomia Center, Department of Neurology, NYU Langone Medical Center, NY (J.-A.P., J.M., H.K.).
Horacio KaufmannDysautonomia Center, Department of Neurology, NYU Langone Medical Center, NY (J.-A.P., J.M., H.K.).
Italo BiaggioniVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (C.A.S., J.E.C., I.B.).
NYU Langone Health · USVanderbilt University · US

Funding

Phase 2 Norepinephrine Transporter Blockade, Autonomic Failure IND117394 12/28/12R01FD004778 · FDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KAUFMANN, HORACIO, SHIBAO, CYNDYA ADRIANA · 2016 to 2019
$1.6M
FDA HHS R01 FD004778
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Adrenergic Uptake InhibitorsAgedAtomoxetine HydrochlorideBlood PressureFemaleHumansHypotension, OrthostaticMaleMiddle AgedMultiple System AtrophyNorepinephrineParkinson DiseasePure Autonomic FailureRetrospective StudiesAdrenergic Uptake InhibitorsAtomoxetine HydrochlorideNorepinephrinebiomarkerhypotension, orthostaticnorepinephrineParkinson diseasepure autonomic failure

Identifiers

PMID34176285
PMCPMC9192331
OpenAlexW3175425221

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.